Evidence map›Paper›PMID 30426325›Full record

ArticleMycotoxin research2019

Interaction of the mycotoxin metabolite dihydrocitrinone with serum albumin.

Zelma Faisal, Virág Vörös, Beáta Lemli, Diána Derdák, Sándor Kunsági-Máté, Mónika Bálint, Csaba Hetényi, Rita Csepregi, Tamás Kőszegi, Dominik Bergmann and 4 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Mycotoxin research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Zelma FaisalDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Virág VörösDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Beáta LemliJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, Pécs, 7624, Hungary.
Diána DerdákJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, Pécs, 7624, Hungary.
Sándor Kunsági-MátéJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, Pécs, 7624, Hungary.
Mónika BálintDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Csaba HetényiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary.
Rita CsepregiJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, Pécs, 7624, Hungary.
Tamás KőszegiJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, Pécs, 7624, Hungary.
Dominik BergmannInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 45, 48149, Münster, Germany.
Franziska SueckInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 45, 48149, Münster, Germany.
Hans-Ulrich HumpfInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 45, 48149, Münster, Germany.
Florian HübnerInstitute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstr. 45, 48149, Münster, Germany.
Miklós PoórDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, Pécs, 7624, Hungary. poor.miklos@pte.hu.
University of Pecs · HUUniversity of Münster · DE

Funding

Deutsche Forschungsgemeinschaft GRK1143Hungarian National Research, Development and Innovation Office FK125166Hungarian National Research, Development and Innovation Office K123836
6 · The paper itself

Abstract

Citrinin (CIT) is a nephrotoxic mycotoxin produced by Penicillium, Monascus, and Aspergillus species. CIT appears as a contaminant in cereals, cereal-based products, fruits, nuts, and spices. During the biotransformation of CIT, its major urinary metabolite dihydrocitrinone (DHC) is formed. Albumin interacts with several compounds (including mycotoxins) affecting their tissue distribution and elimination. CIT-albumin interaction is known; however, the complex formation of DHC with albumin has not been reported previously. In this study, we aimed to investigate the interaction of DHC with albumin, employing fluorescence spectroscopy, circular dichroism, and molecular modeling studies. Furthermore, species differences and thermodynamics of the interaction as well as the effects of albumin on the acute in vitro toxicity of DHC and CIT were also tested. Our main observations/conclusions are as follows: (1) Fluorescence signal of DHC is strongly enhanced by albumin. (2) Formation of DHC-albumin complexes is supported by both fluorescence spectroscopic and circular dichroism studies. (3) DHC forms similarly stable complexes with human albumin (K~10

Indexed as

AnimalsCattleCircular DichroismCitrininHumansMolecular Dynamics SimulationMycotoxinsPoisonsProtein BindingRatsSerum AlbuminSpectrometry, FluorescenceSwineCitrinindihydrocitrinoneMycotoxinsPoisonsSerum AlbuminAlbumin-ligand interactionCitrininDihydrocitrinoneFluorescence spectroscopySerum albumin

Identifiers

PMID30426325
OpenAlexW2900583906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.