ReviewJournal of industrial microbiology & biotechnology2019
Metabolic engineering for improving L-tryptophan production in Escherichia coli.
Review in Journal of industrial microbiology & biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Biosensor-driven evolution and metabolic engineering of an Escherichia coli cell factory for L-tryptophan production.Microbial cell factories · 2026Article
- A Reassessment of Tryptophan Requirements for Aged Brown Laying Hens Using Amino Acid Biomass.Animals : an open access journal from MDPI · 2026Article
- Optimizing L-Tryptophan Production inJournal of microbiology and biotechnology · 2025Article
- Maternal microbial effects and the dynamic distribution, networks, and functions of pig gut microbiota across the entire life cycle.Scientific reports · 2025Article
- Systems metabolic engineering ofSynthetic and systems biotechnology · 2025Article
- Aromatic Amino Acids: Exploring Microalgae as a Potential Biofactory.Biotech (Basel (Switzerland)) · 2025Review
- Tryptophan production by catalysis of a putative tryptophan synthase protein.Archives of microbiology · 2024Article
- Tryptophan-Based Hyperproduction of Bioindigo by Combinatorial Overexpression of Two Different Tryptophan Transporters.Journal of microbiology and biotechnology · 2024Article
- New Target Gene Screening Using Shortened and Random sgRNA Libraries in Microbial CRISPR Interference.ACS synthetic biology · 2023Article
- A comprehensive review and comparison of L-tryptophan biosynthesis inFrontiers in bioengineering and biotechnology · 2023Review
- Analysis of the Propionate Metabolism inMicroorganisms · 2022Article
- Simulation of Adsorption Process of l-Tryptophan on Mixed-Mode Resin HD-1 with Combined Physical Adsorption and Ion Exchange.ACS omega · 2022Article
- Metabolic control analysis enables rational improvement of E. coli L-tryptophan producers but methylglyoxal formation limits glycerol-based production.Microbial cell factories · 2022Article
- Microbial pigments: Learning from Himalayan perspective to industrial applications.Journal of industrial microbiology & biotechnology · 2022Article
- Fermentative Indole Production via Bacterial Tryptophan Synthase Alpha Subunit and Plant Indole-3-Glycerol Phosphate Lyase Enzymes.Journal of agricultural and food chemistry · 2022Article
- Adsorption Equilibria, Kinetics, and Column Dynamics of L-Tryptophan on Mixed-Mode Resin HD-1.ACS omega · 2022Article
- Advances and prospects in metabolic engineering of Escherichia coli for L-tryptophan production.World journal of microbiology & biotechnology · 2022Review
- Tryptophan Production Maximization in a Fed-Batch Bioreactor with ModifiedBioengineering (Basel, Switzerland) · 2021Article
- Metabolic control analysis of L-tryptophan producing Escherichia coli applying targeted perturbation with shikimate.Bioprocess and biosystems engineering · 2021Article
- Pathway engineering ofMetabolic engineering communications · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
L-Tryptophan is an important aromatic amino acid that is used widely in the food, chemical, and pharmaceutical industries. Compared with the traditional synthetic methods, production of L-tryptophan by microbes is environmentally friendly and has low production costs, and feed stocks are renewable. With the development of metabolic engineering, highly efficient production of L-tryptophan in Escherichia coli has been achieved by eliminating negative regulation factors, improving the intracellular level of precursors, engineering of transport systems and overexpression of rate-limiting enzymes. However, challenges remain for L-tryptophan biosynthesis to be cost-competitive. In this review, successful and applicable strategies derived from metabolic engineering for increasing L-tryptophan accumulation in E. coli are summarized. In addition, perspectives for further efficient production of L-tryptophan are discussed.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.