Evidence map›Paper›PMID 30426264›Full record

ArticleAIDS and behavior2019

Late Presentation and Missed Opportunities for HIV Diagnosis in Guatemala.

Johanna Meléndez, Samuel W Reinhardt, Jane A O'Halloran, Andrej Spec, Andrea Alonzo Cordon, William G Powderly, Carlos Mejia Villatoro

Open access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Variability in Human Immunodeficiency Virus infection screening: impact of the COVID-19 pandemic.Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025
    Observational
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Observational
  9. Impact of the COVID-19 pandemic on HIV care in Guatemala.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Johanna MeléndezDepartment of Internal Medicine, Infectious Diseases Clinic, Roosevelt Hospital, Calzada Roosevelt y 5ª. Calle, zona 11, 01100, Guatemala City, Guatemala. jrmm24@yahoo.com.
Samuel W ReinhardtDepartment of Medicine, Washington University School of Medicine, 4523 Clayton Ave., Campus Box 8058, St. Louis, MO, 63110, USA.
Jane A O'HalloranDivision of Infectious Diseases, Washington University School of Medicine, 4523 Clayton Ave., Campus Box 8051, St. Louis, MO, 63110, USA.
Andrej SpecDivision of Infectious Diseases, Washington University School of Medicine, 4523 Clayton Ave., Campus Box 8051, St. Louis, MO, 63110, USA. andrejspec@wustl.edu.
Andrea Alonzo CordonDepartment of Internal Medicine, Infectious Diseases Clinic, Roosevelt Hospital, Calzada Roosevelt y 5ª. Calle, zona 11, 01100, Guatemala City, Guatemala.
William G PowderlyDivision of Infectious Diseases, Washington University School of Medicine, 4523 Clayton Ave., Campus Box 8051, St. Louis, MO, 63110, USA.
Carlos Mejia VillatoroDepartment of Internal Medicine, Infectious Diseases Clinic, Roosevelt Hospital, Calzada Roosevelt y 5ª. Calle, zona 11, 01100, Guatemala City, Guatemala.
Washington University in St. Louis · USRoosevelt Hospital · GT

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1TR002345
6 · The paper itself

Abstract

Early HIV diagnosis remains a challenge in many regions with delayed diagnosis resulting in increased morbidity and mortality. We conducted a retrospective cohort study of people living with HIV receiving outpatient care at a large tertiary referral center in Guatemala to describe the proportion of late presenters (LP) and missed opportunities for HIV diagnosis. Of 3686 patients, 2990 (81.1%) were LP who were more likely to be male (60.2% vs. 48.0%, p < 0.0001), heterosexual (88.0% vs. 78.0%, p < 0.0001) and rural dwellers (43.7% vs. 33.8%. p < 0.0001). The proportions of patients who presented late or with AIDS at diagnosis decreased over time. Only 665 patients (18.2%) sought care in the 2 years prior to HIV diagnosis. This study, the first of its kind in Central America to focus on late presenters and missed opportunities for HIV diagnosis, demonstrates extremely high rates of LP in Guatemala. Although in recent years rates of LP have improved somewhat, the need for screening outside of traditional healthcare settings is apparent.

Indexed as

Delayed DiagnosisAdultAge FactorsAmbulatory CareCD4 Lymphocyte CountEarly DiagnosisFemaleGuatemalaHeterosexualityHIV InfectionsHomosexualityHumansMaleMiddle AgedPrimary Health CareRetrospective StudiesAIDSDiagnosisGuatemalaHIV

Identifiers

PMID30426264
PMCPMC7397713
OpenAlexW2901922032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.