ArticlePediatric nephrology (Berlin, Germany)2019
Central systolic blood pressure and central pulse pressure predict left ventricular hypertrophy in hypertensive children.
Article in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Elevated Blood Pressure and Cardiac Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis.American journal of hypertension · 2025Pooled it
- Association of blood pressure, obesity and physical activity with arterial stiffness in children: a systematic review and meta-analysis.Pediatric research · 2022Pooled it
- Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression.Frontiers in cardiovascular medicine · 2022Pooled it
- Effect and Mechanism of a New Method of Low-Intensity Resistance Training Combined with Blood Flow Restriction on Sports Biomechanics of Young People.Journal of sports science & medicine · 2025Trial
- Aerobic Training Attenuates Differences Between Black and White Adults in Left Ventricular-Vascular Coupling and Wasted Pressure Effort.Journal of the American Heart Association · 2024Trial
- Central and peripheral vascular recovery following resistance exercise with and without blood flow restriction across age groups: a parallel group crossover randomized trial.European journal of applied physiology · 2026Article
- Vascular and blood pressure alterations in children two years after multisystem inflammatory syndrome.Scientific reports · 2026Article
- Development and Validation of a Nomogram-Based Model to Predict Primary Hypertension Within the Next Year in Children and Adolescents: Retrospective Cohort Study.Journal of medical Internet research · 2024Article
- Pathophysiology of primary hypertension in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2024Review
- Pulse Wave Analysis in Obese Children with and without Metabolic SyndromeJournal of clinical research in pediatric endocrinology · 2023Article
- Vascular phenotypes in early hypertension.Journal of human hypertension · 2023Article
- The significance of central blood pressure for cardiovascular target organ damage in children and adolescents after kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2023Article
- Early vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies.Amino acids · 2023Article
- Demographics of childhood hypertension in the UK: a report from the Southeast England.Journal of human hypertension · 2023Article
- Evaluation of Active Renin Concentration in A Cohort of Adolescents with Primary Hypertension.International journal of environmental research and public health · 2022Article
- 24-hour central blood pressure and immune system activation in adolescents with primary hypertension - a preliminary study.Central-European journal of immunology · 2022Article
- Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study.Journal of human hypertension · 2021Article
- Could arterial stiffness be early reversible target organ damage test in childhood hypertension?Anatolian journal of cardiology · 2021Article
- Obesity, metabolic syndrome, and primary hypertension.Pediatric nephrology (Berlin, Germany) · 2021Article
- Should we need more sensitive early diagnostic markers in children with congenital solitary functioning kidneys?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCentral systolic and pulse pressures are stronger predictors of cardiovascular risk and hypertensive organ damage than brachial blood pressure. It is suggested that isolated systolic hypertension typically seen in adolescents is associated with normal central blood pressure and does not lead to organ damage and this phenomenon is called spurious hypertension.
methodsWe assessed the prevalence of spurious hypertension and analyzed utility of pulse wave analysis as determinant of hypertensive organ damage in 294 children (62 girls; 15.0 ± 2.4 years) diagnosed as primary hypertension. White coat hypertension, ambulatory prehypertension, ambulatory hypertension, and severe ambulatory hypertension were diagnosed in 127, 29, 41, and 97 patients, respectively.
resultsNormal central blood pressure was found in 100% in patients with white coat hypertension, 93% in pre-hypertensives, 51.2% in those with ambulatory hypertension, and 27.8% with severe ambulatory hypertension (p = 0.0001). Children with severe ambulatory hypertension had higher central systolic and pulse pressure, pulse wave velocity, and greater prevalence of left ventricular hypertrophy than white coat and prehypertensive children (p < 0.05). Left ventricular mass index and carotid intima-media thickness correlated with central systolic and pulse pressure (p < 0.05 for all). Receiver operating curve area was similar for augmentation pressure (0.5836), 24-h ambulatory systolic blood pressure (0.5841), central systolic blood pressure (0.6090), and central pulse pressure (0.5611) as predictors of left ventricular hypertrophy.
conclusionsThese findings suggest that pulse wave analysis is complementary to ambulatory blood pressure monitoring in assessment of risk of organ damage in hypertensive adolescents.
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