ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2019
A major QTL and candidate genes for capsaicinoid biosynthesis in the pericarp of Capsicum chinense revealed using QTL-seq and RNA-seq.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 62 citations in OpenAlex.
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- Genetic characterization of a locus responsible for low pungency using EMS-induced mutants in Capsicum annuum L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Development of a 45K pepper GBTS liquid-phase gene chip and its application in genome-wide association studies.Frontiers in plant science · 2024Article
- A major QTL identification and candidate gene analysis of watermelon fruit cracking using QTL-seq and RNA-seq.Frontiers in plant science · 2023Article
- Antifungal Potential of Capsaicinoids and Capsinoids from theMicroorganisms · 2022Review
- Analysis of transcriptome data and quantitative trait loci enables the identification of candidate genes responsible for fiber strength in Gossypium barbadense.G3 (Bethesda, Md.) · 2022Article
- Heterosis for capsacinoids accumulation in chili pepper hybrids is dependent on parent-of-origin effect.Scientific reports · 2022Article
- Fruity, sticky, stinky, spicy, bitter, addictive, and deadly: evolutionary signatures of metabolic complexity in the Solanaceae.Natural product reports · 2022Review
- Fine mapping and analysis of candidate genes for qFT7.1, a major quantitative trait locus controlling flowering time in Brassica rapa L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Detection of a major QTL and development of KASP markers for seed weight by combining QTL-seq, QTL-mapping and RNA-seq in peanut.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Harnessing the potential of bulk segregant analysis sequencing and its related approaches in crop breeding.Frontiers in genetics · 2022Review
- Oxidative stress response and programmed cell death guided by NAC013 modulate pithiness in radish taproots.The Plant journal : for cell and molecular biology · 2022Article
- Chile Pepper (Frontiers in plant science · 2022Review
- Investigation of genetic factors regulating chlorophyll and carotenoid biosynthesis in red pepper fruit.Frontiers in plant science · 2022Article
- Identification of QTL and candidate genes associated with biomass yield and Feed Quality in response to water deficit in alfalfa (Frontiers in plant science · 2022Article
- Characterization of the genetic and regulatory networks associated with sugar and acid metabolism in applesFrontiers in plant science · 2022Article
- Capsaicinoid biosynthesis in the pericarp of chili pepper fruits is associated with a placental septum-like transcriptome profile and tissue structure.Plant cell reports · 2021Article
- QTL Mapping and Diurnal Transcriptome Analysis Identify Candidate Genes RegulatingInternational journal of molecular sciences · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
key messageA major QTL and candidate genes controlling capsaicinoid content in the pericarp were identified by QTL-seq and RNA-seq in Capsicum chinense. Capsaicinoid biosynthesis was previously thought to be restricted to the placental tissue; however, the recent discovery of their biosynthesis in the pericarp provides new opportunities to increase the capsaicinoid content in pepper fruits. Currently, the genetic mechanisms regulating capsaicinoid biosynthesis in the pericarp remain unknown. Here, we performed quantitative trait loci (QTL) mapping and RNA sequencing (RNA-seq) to reveal the genes controlling capsaicinoid biosynthesis in the pericarp. A whole-genome sequencing-based QTL-seq strategy was employed, identifying a major QTL on chromosome 6. To validate the QTL on chromosome 6, we performed traditional QTL mapping using the same population in QTL-seq with an additional biparental population. A total of 15 QTLs for capsaicinoid content distributed on chromosomes 3, 6, and 11 were newly identified. Among these QTLs, the genetic loci on the lower arm of chromosome 6 were commonly detected in the two mapping populations, corresponding to the location of the major QTL detected using whole-genome sequencing-based QTL-seq. Our RNA-seq analysis identified candidate genes within the common QTL that were differentially expressed in the pungent and non-pungent pericarp tissues. Our results are expected to contribute to the elucidation of the regulation of capsaicinoid biosynthesis. We also demonstrated that a combination of QTL mapping and RNA-seq is helpful for refining the candidate genes of a complicated trait of interest.
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