ArticleDiabetologia2019
Gestational diabetes in young women predicts future risk of serious liver disease.
Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Long-Term Follow-Up on Morbidity Among Women With a History of Gestational Diabetes Mellitus: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2020Pooled it
- A Review of Traditional and Non-Traditional Cardiovascular Risk Factors in Women.International journal of women's health · 2026Review
- Association between isolated abnormal 1-hour glucose challenge test and adverse pregnancy outcomes: a retrospective review from an urban tertiary care center in the United States.BMC pregnancy and childbirth · 2025Article
- A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism.Frontiers in endocrinology · 2025Article
- Gestational diabetes mellitus and development of intergenerational non-alcoholic fatty liver disease (NAFLD) after delivery: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Gestational diabetes mellitus and risk of long-term all-cause and cardiac mortality: a prospective cohort study.Cardiovascular diabetology · 2024Article
- Gestational Diabetes Mellitus and Its Implications across the Life Span.Diabetes & metabolism journal · 2023Review
- The life course perspective of gestational diabetes: An opportunity for the prevention of diabetes and heart disease in women.EClinicalMedicine · 2022Review
- The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts.Biological research · 2021Article
- Molecular Modelling of Islet β-Cell Adaptation to Inflammation in Pregnancy and Gestational Diabetes Mellitus.International journal of molecular sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIn common with type 2 diabetes, gestational diabetes mellitus (GDM) is associated with a propensity for hepatic fat deposition. We hypothesised that GDM predicts future lifetime risk of serious liver-disease outcomes, such as cirrhosis, liver failure and need for transplantation.
methodsFrom population-based administrative databases, we identified all women in Ontario, Canada, who had a pregnancy resulting in live birth between April 1994 and March 2002 (N = 698,078). This population was stratified into individuals with (n = 17,932) and without (n = 680,146) GDM, and both groups were further stratified according to subsequent development of type 2 diabetes in the years after delivery. The median follow-up for the development of serious liver disease (defined as hospitalisation for cirrhosis, liver failure or transplantation) was 14.0 years.
resultsWomen with GDM had a higher risk of serious liver disease than those without GDM (n = 680,146; HR = 1.40, 95% CI 1.01, 1.94). Compared with women who did not have GDM and did not develop diabetes (n = 635,998), those with GDM who subsequently developed type 2 diabetes (n = 8567) had a higher risk of serious liver disease (adjusted HR = 1.56, 95% CI 1.02, 2.39), as did those without GDM who developed type 2 diabetes (n = 44,148; adjusted HR = 2.48, 95% CI 2.10, 2.93), but not those with GDM who did not develop type 2 diabetes (n = 9365; adjusted HR = 1.15, 95% CI 0.69, 1.91). CONCLUSION/
interpretationGDM is associated with future risk of serious liver disease in young women, the development of which may be dependent upon progression to non-gestational diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.