Evidence map›Paper›PMID 30425970›Full record

ArticleFrontiers in cellular and infection microbiology2018

Highly Potent 1

Sumit Kumar, Trpta Bains, Ashley Sae Won Kim, Christina Tam, Jong Kim, Luisa W Cheng, Kirkwood M Land, Anjan Debnath, Vipan Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sumit KumarDepartment of Chemistry, Guru Nanak Dev University, Amritsar, India.
Trpta BainsCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.
Ashley Sae Won KimDepartment of Biological Sciences, University of the Pacific, Stockton, CA, United States.
Christina TamFoodborne Toxin Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA, United States.
Jong KimFoodborne Toxin Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA, United States.
Luisa W ChengFoodborne Toxin Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA, United States.
Kirkwood M LandDepartment of Biological Sciences, University of the Pacific, Stockton, CA, United States.
Anjan DebnathCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.
Vipan KumarDepartment of Chemistry, Guru Nanak Dev University, Amritsar, India.
Guru Nanak Dev University · INUnited States Department of Agriculture · USUniversity of California, San Diego · USUniversity of the Pacific · USAgricultural Research Service · US

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
NCATS NIH HHS KL2 TR001444
6 · The paper itself

Abstract

Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical and subtropical regions of the world. Metronidazole (MTZ) is the current drug of choice for amebiasis, giardiasis, and trichomoniasis but it has several adverse effects and potential resistance is a concern. In order to develop alternative antimicrobials, a library of 1

Indexed as

AnaerobiosisAntiprotozoal AgentsEntamoeba histolyticaFoodborne DiseasesGiardia lambliaHumansInhibitory Concentration 50IsatinMetronidazoleParasitic DiseasesParasitic Sensitivity TestsSexually Transmitted DiseasesTriazolesTrichomonas vaginalisTritrichomonas foetusAntiprotozoal AgentsIsatinMetronidazoleTriazolescytotoxicityEntamoeba histolyticaGiardia lambliaisatin-metronidazole conjugatesmetronidazoleTrichomonas vaginalisTritrichomonas foetus

Identifiers

PMID30425970
PMCPMC6218680
OpenAlexW2896282563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.