ArticleFrontiers in endocrinology2018
Insulin-Related Lipohypertrophy: Lipogenic Action or Tissue Trauma?
Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Lipodystrophy and associated factors among patients with diabetes receiving insulin therapy: a multicenter study in Ethiopia.Scientific reports · 2026Article
- Basal-bolus regimen versus twice-daily premixed insulin in the treatment of childhood type 1 diabetes mellitus in Mosul City: A comparison study.Problemy endokrinologii · 2026Article
- Development of a diagnostic model of insulin-related lipohypertrophy for patients with diabetes mellitus.Journal of diabetes investigation · 2025Article
- iGlarLixi: A titrateable fixed-ratio combination of basal insulin + GLP-1 receptor agonist-An effective type 2 diabetes treatment option in China.Diabetes, obesity & metabolism · 2025Review
- Premixed insulin: Advantages, disadvantages, and future.World journal of diabetes · 2025Article
- Transitioning to Insulin Analogs in Tunisian Children with Type 1 Diabetes: Efficacy and Safety.La Tunisie medicale · 2024Article
- Optimising Insulin Injection Techniques to Improve Diabetes Outcomes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Review
- Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center.Acta bio-medica : Atenei Parmensis · 2023Article
- Needle Technology for Insulin Administration: A Century of Innovation.Journal of diabetes science and technology · 2023Review
- Financial burden for families of children with type 1 diabetes: a cross-sectional survey from North India.Diabetology international · 2022Article
- Insulin-related lipohypertrophy: ultrasound characteristics, risk factors, and impact of glucose fluctuations.Endocrine · 2022Article
- Gender Differences in Prevalence and Clinical Correlates of Lipohypertrophy in Insulin-Exposed Patients with Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Lipohypertrophy prevalence and its associated risk factors in insulin-treated patients with type 2 diabetes in North Borneo, Malaysia.Belitung nursing journal · 2022Article
- Insulin-induced Lipohypertrophy in Patients with Type 1 Diabetes Mellitus Treated with an Insulin Pump.International journal of endocrinology · 2022Article
- Characteristics and morphology of lipohypertrophic lesions in adults with type 1 diabetes with ultrasound screening: an exploratory observational study.BMJ open diabetes research & care · 2021Observational
- Insulin-Induced Skin Lipohypertrophy in Type 2 Diabetes: a Multicenter Regional Survey in Southern Italy.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
- Extent of lipohypertrophy in diabetic patients-Sometimes much more than meets the eye.Clinical case reports · 2019Article
- Prevalence of Lipohypertrophy and its Associations in Insulin-Treated Diabetic Patients.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipohypertrophy has been suggested as an outcome of lipogenic action of insulin and/or injection-related tissue trauma. In a cross-sectional study, we evaluated the predictors of lipohypertrophy in 372 type 1 diabetes patients (mean age 17.1 years) receiving subcutaneous insulin with pen and/or syringes for ≥3 months. On examining injection sites with inspection and palpation technique, 62.1% patients demonstrated lipohypertrophy. Univariate analysis showed that gender, BMI, HbA1c, injection device, rotation, injection area, needle length, insulin regimen, and total daily dose of insulin were associated with lipohypertrophy (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.