ArticleFrontiers in neuroanatomy2018
Reconstruction of Intratelencephalic Neurons in the Mouse Secondary Motor Cortex Reveals the Diverse Projection Patterns of Single Neurons.
Article in Frontiers in neuroanatomy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 40 citations in OpenAlex.
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- Connectivity of single neurons classifies cell subtypes in mouse brains.Nature methods · 2025Article
- From Individual to Population: Circuit Organization of Pyramidal Tract and Intratelencephalic Neurons in Mouse Sensorimotor Cortex.Research (Washington, D.C.) · 2024Article
- Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuronal Connectivity as a Determinant of Cell Types and Subtypes.Research square · 2023Article
- M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Different effects of I-wave periodicity repetitive TMS on motor cortex interhemispheric interaction.Frontiers in neuroscience · 2023Article
- Corticocortical innervation subtypes of layer 5 intratelencephalic cells in the murine secondary motor cortex.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Brain-wide projection reconstruction of single functionally defined neurons.Nature communications · 2022Article
- Transcranial Magnetic Stimulation and Neocortical Neurons: The Micro-Macro Connection.Frontiers in neuroscience · 2022Review
- Transduction of Systemically Administered Adeno-Associated Virus in the Colonic Enteric Nervous System and c-Kit Cells of Adult Mice.Frontiers in neuroanatomy · 2022Article
- Benchmarking of tools for axon length measurement in individually-labeled projection neurons.PLoS computational biology · 2021Article
- Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex.Neuroscience bulletin · 2021Article
- Secondary motor cortex: Broadcasting and biasing animal's decisions through long-range circuits.International review of neurobiology · 2021Review
- Anatomically revealed morphological patterns of pyramidal neurons in layer 5 of the motor cortex.Scientific reports · 2020Article
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- Focal neocortical lesions impair distant neuronal information processing.The Journal of physiology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The secondary motor cortex (MOs) plays crucial roles in cognitive and executive processes and has reciprocal connections with numerous cortices in rodents. However, descriptions of the neuronal morphologies and projection patterns of the MOs at the level of a single neuron are lacking, severely hindering the comprehensive understanding of the wiring diagram of the MOs. Herein, we used a Cre-dependent adeno-associated virus (AAV) to fluorescently label ~80 pyramidal neurons nearby or in the MOs and acquired an uninterrupted whole-brain 3D dataset at a voxel resolution of 0.2 × 0.2 × 1 μm with a whole-brain fluorescence imaging system (fMOST). Based on our 3D dataset, we reconstructed the complete morphologies of 36 individual intratelencephalic (IT) neurons nearby or in the MOs and analyzed the projection patterns and projection strengths of these neurons at a single-neuron level based on several parameters, including the projection areas, the total number of branches, the fiber length, and the total number of terminal tips. We obtained a neuron with an axonal length of 318.43 mm, which is by far the longest reported axonal length. Our results show that all individual neurons in the MOs, regardless of whether they are located in layer 2/3 or layer 5, display diverse projection patterns and projection strengths, implying that these neurons might be involved in different brain circuits at different intensities. The results lay a solid foundation for exploring the relationship between neuronal morphologies and behavioral functions of the MOs at the level of a single neuron.
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