ArticleCancer management and research2018
Type-specific high-risk human papillomavirus viral load as a viable triage indicator for high-grade squamous intraepithelial lesion: a nested case- control study.
Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Association between HPV-16 and HPV-18 viral loads and severity of cervical pre-invasive lesions in women with and without HIV in Botswana.Frontiers in oncology · 2026Article
- Human Papillomavirus Viral Load as Triage Biomarker for High-Grade Cervical Lesions and Invasive Cervical Carcinoma: A Cross-Sectional Study.Health science reports · 2025Article
- Assessment of risk factors for high-grade cervical or endometrial lesions to triage women with AGC-FN: a retrospective study.BMC women's health · 2025Article
- A study of HPV self-sampling by female residents in communities of Zhengzhou, Henan Province, China: a cross-sectional observational study.Frontiers in public health · 2025Observational
- Classification and diagnosis of cervical lesions based on colposcopy images using deep fully convolutional networks: A man-machine comparison cohort study.Fundamental research · 2025Article
- RAP1-GTPase immunostaining is altered in human precancerous and cancerous cervical lesions.Biomarkers in medicine · 2024Article
- Detection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears.Frontiers in oncology · 2024Article
- Molecular pathways in the development of HPV-induced oropharyngeal cancer.Cell communication and signaling : CCS · 2023Article
- Multiple infections containing the top five prevalent HPV genotypes and their impact on cervical lesions in Changzhou, China.Human vaccines & immunotherapeutics · 2023Article
- Evaluation of Human Papilloma Virus (HPV) Genotyping and Viral Load Determination as Diagnostic Biomarkers of Cervical Cancer Risk.International journal of molecular sciences · 2023Article
- Association and Effectiveness of PAX1 Methylation and HPV Viral Load for the Detection of Cervical High-Grade Squamous Intraepithelial Lesion.Pathogens (Basel, Switzerland) · 2022Article
- Age-Stratified Analysis of Vaginal Microbiota Dysbiosis and the Relationship with HPV Viral Load in HPV-Positive Women.Journal of immunology research · 2022Article
- The safety and efficacy of a novel method for treatment of HSIL.Archives of gynecology and obstetrics · 2021Observational
- Significance of the viral load of high-risk HPV in the diagnosis and prediction of cervical lesions: a retrospective study.BMC women's health · 2021Article
- Electrochemical Strategy for Low-Cost Viral Detection.ACS central science · 2021Article
- Diagnostic value of high-risk human papillomavirus viral load on cervical lesion assessment and ASCUS triage.Cancer medicine · 2021Article
- Analysis of influencing factors of viral load in patients with high-risk human papillomavirus.Virology journal · 2021Article
- Correlation between multi-type human papillomavirus infections and viral loads and the cervical pathological grade.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021Article
- Effect of introducing human papillomavirus genotyping into real-world screening on cervical cancer screening in China: a retrospective population-based cohort study.Therapeutic advances in medical oncology · 2021Article
- Use of extended HR-HPV Genotyping in improving the Triage Strategy of 2019 ASCCP recommendations in Women with positive HR-HPV diagnosis and Simultaneous LSIL Cytology Results.Journal of Cancer · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCurrently, the associations between type-specific high-risk human papillomavirus (HR-HPV) viral loads and cervical lesions are still inconsistent. We aimed to assess the type-specific HR-HPV viral load as a risk triage indicator for development of high-grade squamous intraepithelial lesion or worse (≥HSIL). PATIENTS AND
methodsA total of 19,446 women who underwent primary screening for cervical cancer using Cervista
resultsThe viral loads of HPV-16, -31, -33, -52, and -58 were positively correlated with the severity of the cervical lesion, which was significantly elevated in patients with ≥HSIL, whereas those of HPV-18, -45, -56, -59, and other types were not. The optimal cutoffs of the log
conclusionThe BioPerfectus Multiplex Real-Time PCR viral load assay provides viable triage for ≥HSIL when using appropriate cutoff levels.
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