Evidence map›Paper›PMID 30425540›Full record

ReviewInfection and drug resistance2018

Systematic review in South Africa reveals antibiotic resistance genes shared between clinical and environmental settings.

Mutshiene Deogratias Ekwanzala, John Barr Dewar, Ilunga Kamika, Maggy Ndombo Benteke Momba

Abstract readReview
In one paragraph

Review in Infection and drug resistance, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. EFFECT OFAfrican journal of infectious diseases · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Trends and Progress on Antibiotic-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
  11. Carbapenem resistance inAIMS microbiology · 2023
    Review
  12. Antimicrobial resistance genes ofAIMS microbiology · 2023
    Review
  13. Article
  14. Article
  15. Antimicrobial Susceptibility Profiles amongPathogens (Basel, Switzerland) · 2022
    Article
  16. Review
  17. Genetic Characterization of Antibiotic ResistantFrontiers in microbiology · 2022
    Article
  18. Beta-lactamase resistance genes inAfrican journal of laboratory medicine · 2022
    Review
  19. Article
  20. Human-Associated Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mutshiene Deogratias EkwanzalaDepartment of Environmental, Water and Earth Sciences, Tshwane University of Technology, Pretoria, South Africa, mombamnb@tut.ac.za.
John Barr DewarDepartment of Life and Consumer Sciences, University of South Africa, Johannesburg, South Africa.
Ilunga KamikaDepartment of Environmental, Water and Earth Sciences, Tshwane University of Technology, Pretoria, South Africa, mombamnb@tut.ac.za.
Maggy Ndombo Benteke MombaDepartment of Environmental, Water and Earth Sciences, Tshwane University of Technology, Pretoria, South Africa, mombamnb@tut.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic review was conducted to determine the distribution and prevalence of antibiotic-resistant bacteria (ARB), antimicrobial-resistant genes (ARGs), and antimicrobial-resistant gene determinants (ARGDs) in clinical, environmental, and farm settings and to identify key knowledge gaps in a bid to contain their spread. Fifty-three articles were included. The prevalence of a wide range of antimicrobial-resistant bacteria and their genes was reviewed. Based on the studies reviewed in this systematic review, mutation was found to be the main genetic element investigated. All settings shared 39 ARGs and ARGDs. Despite the fact that ARGs found in clinical settings are present in the environment, in reviewed articles only 12 were found to be shared between environmental and clinical settings; the inclusion of farm settings with these two settings increased this figure to 32. Data extracted from this review revealed farm settings to be one of the main contributors of antibiotic resistance in healthcare settings. ARB, ARGs, and ARGDs were found to be ubiquitous in all settings examined.

Indexed as

ARBARGDsclinical ARGsenvironmental ARGsSouth Africasystematic review

Identifiers

PMID30425540
PMCPMC6203169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.