Evidence map›Paper›PMID 30425510›Full record

ArticleOncoTargets and therapy2018

Dosimetric comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy in patients with cervical cancer: a meta-analysis.

Wei Bai, Changgui Kou, Weiying Yu, Yuanyuan Li, Wanqing Hua, Lei Yu, Jianfeng Wang

Open access · goldAbstract read
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Outcome and toxicity of chemoradiation using volumetric modulated arc therapy followed by 3D image-guided brachytherapy for cervical cancer: Vietnam National Cancer Hospital experience.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wei BaiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Changgui KouDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Weiying YuDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Yuanyuan LiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Wanqing HuaDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Lei YuDepartment of Radiotherapy, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China, yul0826@163.com.
Jianfeng WangDepartment of Radiotherapy, China-Japan Union Hospital, Changchun 130033, Jilin Province, China, jfwang@jlu.edu.cn.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) are two of the main treatment techniques for cervical cancer. Whether either technique significantly reduces irradiated volumes of organs at risk (OARs) remains controversial. The aim of this study was to explore which of these treatment paradigms is the superior technique in cervical treatment, taking clinical outcomes and treatment efficiency from published findings into consideration. MATERIALS AND

methodsPubMed, EMBASE, and Cochrane Library databases were utilized. The average percent irradiated volumes of OAR were extracted from all included studies. Dual arc results were extracted due to their superiority to single arc methods in terms of plan quality. Standard mean deviations and 95% CIs were calculated for delivery time, monitor units, and average percent irradiated volumes of OAR. Assessment of publication bias and sensitivity analyses were performed. All statistical analyses were conducted using R 3.5.0 software.

resultsEight studies were included in this meta-analysis. For irradiated volumes of OARs, irradiated volume of rectum receiving 40 Gy (rectum V40) was significantly decreased in VMAT compared with IMRT. However, no significant differences were observed between IMRT and VMAT plans in bladder V40 or small bowel V40/V30. In addition, delivery times and monitor units were significantly lower in the VMAT plan than in the IMRT plan.

conclusionCompared with IMRT, VMAT is significantly more protective for the rectum, suggesting that it may be an optional therapy technique for patients with cervical cancer.

Indexed as

cervical cancerIMRTmeta-analysisVMAT

Identifiers

PMID30425510
PMCPMC6203086
OpenAlexW2896988419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.