Evidence map›Paper›PMID 30425489›Full record

ArticleInternational journal of nanomedicine2018

The therapeutic effect in gliomas of nanobubbles carrying siRNA combined with ultrasound-targeted destruction.

Wenbin Cai, Wei Lv, Yang Feng, Hengli Yang, Yajun Zhang, Guodong Yang, Yunyou Duan, Jia Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Stimuli-Responsive Nanotechnology for RNA Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  5. Nanoparticles in Medicine: Current Status in Cancer Treatment.International journal of molecular sciences · 2023
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  6. Nucleic acid drug vectors for diagnosis and treatment of brain diseases.Signal transduction and targeted therapy · 2023
    Review
  7. Article
  8. Modification of PEG reduces the immunogenicity of biosynthetic gas vesicles.Frontiers in bioengineering and biotechnology · 2023
    Article
  9. Review
  10. Article
  11. Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery.Frontiers in cell and developmental biology · 2022
    Review
  12. Review
  13. Review
  14. Nanosized Contrast Agents in Ultrasound Molecular Imaging.Frontiers in bioengineering and biotechnology · 2021
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Wenbin CaiDepartment of Ultrasound Diagnosis, Tang Du Hospital, Fourth Military Medical University, Xi'an 710038, China, duanyy@fmmu.edu.cn; lichun@fmmu.edu.cn.
Wei LvDepartment of Ultrasound Diagnosis, Tang Du Hospital, Fourth Military Medical University, Xi'an 710038, China, duanyy@fmmu.edu.cn; lichun@fmmu.edu.cn.
Yang FengXijing Hospital, Traditional Chinese Medicine, Xi'an 710032, China.
Hengli YangDepartment of Ultrasound Diagnosis, Tang Du Hospital, Fourth Military Medical University, Xi'an 710038, China, duanyy@fmmu.edu.cn; lichun@fmmu.edu.cn.
Yajun ZhangDepartment of Ultrasound Diagnosis, Tang Du Hospital, Fourth Military Medical University, Xi'an 710038, China, duanyy@fmmu.edu.cn; lichun@fmmu.edu.cn.
Guodong YangDepartment of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032, China.
Yunyou DuanDepartment of Ultrasound Diagnosis, Tang Du Hospital, Fourth Military Medical University, Xi'an 710038, China, duanyy@fmmu.edu.cn; lichun@fmmu.edu.cn.
Jia WangDepartment of Ultrasound Diagnosis, Tang Du Hospital, Fourth Military Medical University, Xi'an 710038, China, duanyy@fmmu.edu.cn; lichun@fmmu.edu.cn.
Tang Du Hospital · CN307th Hospital of Chinese People’s Liberation Army · CNAir Force Medical University · CNShaanxi Provincial Hospital of Traditional Chinese Medicine · CNTibet Autonomous Region People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNanobubbles (NBs) combined with ultrasound-targeted destruction (UTD) have become promising potential carriers for drug or siRNA delivery. Due to their nano-size, NBs could penetrate tumor blood vessels and accumulate in intercellular spaces so that "sonoporation" induced by UTD would act directly on the tumor cells to increase cell membrane permeability.

methodsBased on the successful the fabrication of NBs, we synthesized NBs carrying siRNA (NBs-siRNA) by using a biotin-streptavidin system. We then utilized ultrasound irradiation (UI)-targeted NBs-siRNA to improve siRNA transfection and achieve the inhibition of glioma growth.

resultsNBs as carriers combined with UI effectively enhanced siRNA transfection and the effect of silencing targeted genes in vitro. Additionally, a better therapeutic effect was shown in the NBs-siRNA with UI group in vivo compared with that of microbubbles (MBs) with UI or NBs-siRNA without UI.

conclusionThese results indicated that NBs combined with UTD might be an ideal delivery vector for siRNA to achieve the noninvasive treatment of glioma.

Indexed as

MicrobubblesUltrasonographyAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalFluorescenceGene Expression Regulation, NeoplasticGliomaHumansMice, NudeNanoparticlesRNA, Small InterferingTransfectionRNA, Small InterferinggliomananobubblessiRNAultrasound

Identifiers

PMID30425489
PMCPMC6205539
OpenAlexW2895803636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.