Evidence map›Paper›PMID 30425454›Full record

ArticleDrug design, development and therapy2018

Antioxidative stress effects of vitamins C, E, and B

Farah M Abdulkhaleq, Tawfiq M Alhussainy, Mujtaba M Badr, Asad A Abu Khalil, Omar Gammoh, Bayan Y Ghanim, Nidal A Qinna

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Farah M AbdulkhaleqDepartment of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan, nqinna@uop.edu.jo.
Tawfiq M AlhussainyDepartment of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan, nqinna@uop.edu.jo.
Mujtaba M BadrUniversity of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, nqinna@uop.edu.jo.
Asad A Abu KhalilUniversity of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, nqinna@uop.edu.jo.
Omar GammohDepartment of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba, Jordan.
Bayan Y GhanimUniversity of Petra Pharmaceutical Center (UPPC), University of Petra, Amman, Jordan, nqinna@uop.edu.jo.
Nidal A QinnaDepartment of Pharmacology and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan, nqinna@uop.edu.jo.
Petra University · JOAmerican University of Madaba · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral vitamins, including C, E, and B MATERIALS AND

methodsAn in vitro model of freshly isolated rat hepatocytes was utilized for assessing hepatocyte mitochondrial activity conducted by cell proliferation assay (MTT). The isolated hepatocytes were treated with vitamin C, vitamin E, vitamin B

resultsIn vitro results showed that vitamins C and B and the combination preparation significantly increased the percentage of hepatocyte mitochondrial activity, both with and without the addition of APAP (

conclusionPretreatment with vitamins C, E, B

Indexed as

AcetaminophenAnimalsAntioxidantsAscorbic AcidChemical and Drug Induced Liver InjuryLiverMaleOxidative StressRatsRats, Sprague-DawleyVitamin B 12Vitamin EAcetaminophenAntioxidantsAscorbic AcidVitamin B 12Vitamin Eglutathionehepatocyteshepatoprotectiveprimary cell cultureproliferationsuperoxide dismutase

Identifiers

PMID30425454
PMCPMC6201998
OpenAlexW2897528830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.