Evidence map›Paper›PMID 30425453›Full record

ArticleDrug design, development and therapy2018

Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy.

Na Du, Zhiping Xu, Mingyue Gao, Peng Liu, Bo Sun, Xia Cao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 5 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  4. Pharmaceutical biology · 2020
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  18. The Ethyl Acetate Extract ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Na DuDepartment of Pharmacology, Jilin University, Jilin, Changchun, China, caoxia@jlu.edu.cn.
Zhiping XuDepartment of Pharmacology, Jilin University, Jilin, Changchun, China, caoxia@jlu.edu.cn.
Mingyue GaoDepartment of Pharmacology, Jilin University, Jilin, Changchun, China, caoxia@jlu.edu.cn.
Peng LiuDepartment of Pharmacology, Jilin University, Jilin, Changchun, China, caoxia@jlu.edu.cn.
Bo SunDepartment of Pharmacology, Jilin University, Jilin, Changchun, China, caoxia@jlu.edu.cn.
Xia CaoDepartment of Pharmacology, Jilin University, Jilin, Changchun, China, caoxia@jlu.edu.cn.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAnti-oxidative stress and inhibition of TGF-β1/Smads signaling cascade are essential therapeutic strategies for diabetic nephropathy (DN). In this study, we aimed to explore the effect of combination of Ginsenoside Rg1 and Astragaloside IV on oxidative stress and TGF-β1/Smads signaling in DN rats. MATERIALS AND

methodsWistar rats were divided into five groups: N group, M group (streptozotocin [STZ], intraperitoneally), G group (STZ rats with Ginsenoside Rg1, intragastrically [ig]), A group (STZ rats with Astragaloside IV, ig) and C group (STZ rats with Ginsenoside Rg1 and Astragaloside IV, ig). The levels of methane dicarboxylic aldehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-PX), total anti-oxidative capacity (T-AOC), blood urea nitrogen (BUN), β

resultsRats in G group, A group and C group had lower level of MDA but higher levels of CAT, GSH-PX and T-AOC compared with rats in M group. Rats in C group showed the best anti-oxidative stress level. G group, A group and C group treatments significantly decreased the levels of BUN, SCr, β

conclusionThe combination of Ginsenoside Rg1 and Astragaloside IV may potentially protect against DN by reducing oxidative stress and inhibiting TGF-β1/Smads signaling cascade.

Indexed as

Administration, OralAnimalsCentral Nervous System AgentsDiabetic NephropathiesDrugs, Chinese HerbalFibrosisGinsenosidesMaleOxidative StressRatsRats, WistarSaponinsSignal TransductionSmad2 ProteinSmad3 ProteinSmad7 Proteinastragaloside ACentral Nervous System AgentsDrugs, Chinese Herbalginsenoside Rg1GinsenosidesSaponinsSmad2 ProteinSmad2 protein, ratSmad3 ProteinSmad3 protein, ratSmad7 ProteinSmad7 protein, ratTgfb1 protein, ratTransforming Growth Factor beta1TriterpenesAstragaloside IVdiabetic nephropathyGinsenoside Rg1oxidative stressSmadsTGF-β1

Identifiers

PMID30425453
PMCPMC6201993
OpenAlexW2896039525

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.