Evidence map›Paper›PMID 30425351›Full record

Trial reportBritish journal of cancer2018

Effect of home-based specialised palliative care and dyadic psychological intervention on caregiver anxiety and depression: a randomised controlled trial.

Annika von Heymann-Horan, Pernille Bidstrup, Mai-Britt Guldin, Per Sjøgren, Elisabeth Anne Wreford Andersen, Hans von der Maase, Jakob Kjellberg, Helle Timm, Christoffer Johansen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01885637 (DOMUS), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01885637 nacompletednot on this map

DOMUS: A Randomized Controlled Clinical Trial of Accelerated Transition From Oncological Treatment to Continuing Palliative Care at Home

TypeinterventionalSponsorRigshospitalet, DenmarkRan2013 to 2019Enrolled340ConditionsIncurable CancerArmsTransition program
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  3. Effects of psychosocial interventions on psychological outcomes among caregivers of advanced cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Annika von Heymann-HoranDanish Cancer Society Research Center, Copenhagen, Denmark. heymann@cancer.dk.ORCID http://orcid.org/0000-0002-0900-5575
Pernille BidstrupDanish Cancer Society Research Center, Copenhagen, Denmark.
Mai-Britt GuldinResearch Unit for General Practice, Aarhus University, Aarhus, Denmark.
Per SjøgrenDepartment of Oncology, Palliative Research Group, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Elisabeth Anne Wreford AndersenDanish Cancer Society Research Center, Copenhagen, Denmark.
Hans von der MaaseDepartment of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Jakob KjellbergKORA, The Danish Institute for Local and Regional Government Research, Copenhagen, Denmark.
Helle TimmKnowledge Center for Rehabilitation and Palliative Care, University of Southern Denmark, Nyborg, Denmark.
Christoffer JohansenDanish Cancer Society Research Center, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpecialised palliative care trials often fail to address intervention effects on caregiver anxiety and depression, particularly in bereavement. We evaluate effects of specialised palliative care and dyadic psychological intervention on caregiver anxiety and depression in a randomised controlled trial (RCT).

methodsPatients with incurable cancer and limited antineoplastic treatment options and their caregivers, recruited from a university hospital oncology department, were randomised (1:1) to care as usual or accelerated transition from oncological treatment to home-based specialised palliative care. We assessed caregivers' symptoms of anxiety and depression with the Symptom Checklist-92 up to six months after randomisation and 19 months into bereavement, and estimated intervention effects in mixed effects models.

resultsThe 'Domus' trial enrolled 258 caregivers. The intervention significantly attenuated increases in caregivers' symptoms of anxiety overall (estimated difference, -0.12; 95% confidence interval, -0.22 to -0.01, p = 0.0266), and symptoms of depression at eight weeks (-0.17; -0.33 to -0.02; p = 0.0314), six months (-0.27; -0.49 to -0.05; p = 0.0165), and in bereavement at two weeks (-0.28; -0.52 to -0.03; p = 0.0295) and two months (-0.24; -0.48 to -0.01; p = 0.0448).

conclusionsThis first RCT evaluating specialised palliative care with dyadic psychological support significantly attenuated caregiver anxiety and depression before and during bereavement. (Clinicaltrials.gov: NCT01885637).

Indexed as

AgedAnxietyCaregiversDepressionFemaleHome Care ServicesHumansMaleMiddle AgedPalliative CarePsychotherapy

Identifiers

PMID30425351
PMCPMC6265292

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.