ArticleScientific reports2018
Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver.Frontiers in endocrinology · 2022Pooled it
- Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review.International journal of environmental research and public health · 2021Pooled it
- Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts.Environment international · 2020Pooled it
- Circulating selenoprotein P levels predict glucose-lowering and insulinotropic effects of metformin, but not alogliptin: A post-hoc analysis.Journal of diabetes investigation · 2023Trial
- Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ-specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes.Journal of diabetes investigation · 2022Trial
- Serum Manganese, Cobalt, Copper, Zinc, Selenium, and Iodine Levels, and the Incidence of Type 2 Diabetes: A Nested Case-control Study.Biological trace element research · 2026Article
- TheJournal of the Endocrine Society · 2025Article
- Article
- Gender differences in plasma element concentrations and associations between selenoprotein P and iron metabolism in a community-based cohort study.Scientific reports · 2025Article
- Selenoprotein-p and insulin resistance in children and adolescents with obesity.World journal of clinical pediatrics · 2024Article
- An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study.Environment international · 2024Article
- Exploring Selenoprotein P in Liver Cancer: Advanced Statistical Analysis and Machine Learning Approaches.Cancers · 2024Article
- Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia.Scientific reports · 2023Article
- Article
- Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023Review
- Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults.Journal of the ASEAN Federation of Endocrine Societies · 2023Article
- Scientific opinion on the tolerable upper intake level for selenium.EFSA journal. European Food Safety Authority · 2023Article
- Selenium status and type 2 diabetes risk.Archives of biochemistry and biophysics · 2022Review
- Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico.Healthcare (Basel, Switzerland) · 2022Article
- Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
We aimed to test the hypothesis that selenoprotein P (SELENOP), a hepatokine involved in the development of both insulin resistance and impaired insulin production in mice, is related to future onset of hyperglycemia in humans. 76 healthy non-pregnant human subjects without diabetes underwent oral glucose tolerance test (OGTT) at baseline and 4-years follow-up. Nine subjects developed either impaired glucose tolerance or type 2 diabetes at follow-up. At baseline, SELENOP concentrations correlated negatively with insulinogenic index, but not with homeostasis model assessment-estimated insulin resistance (HOMA-IR). Multivariate analysis showed that baseline SELENOP predicted fasting plasma glucose at follow-up independently of the other parameters. The receiver operating characteristic (ROC) curve analysis showed that baseline concentrations of serum SELENOP, but not of selenium, were a reliable test to predict future onset of glucose intolerance. In conclusion, elevation of circulating SELENOP, but not of circulating selenium, was positively and independently associated with future onset of glucose intolerance in a general Japanese population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.