ArticleScientific reports2018
Mobilisation Mechanism of Pathogenicity Islands by Endogenous Phages in Staphylococcus aureus clinical strains.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- From hijackers to architects: the role of prophages in bacterial genome evolution.Journal of bacteriology · 2026Review
- Bacillus thuringiensis pathogenicity islands encode regulatory circuits controlling insecticidal Cry toxin expression during vegetative growth.PLoS pathogens · 2026Article
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- Phage parasites targeting phage homologous recombinases provide antiviral immunity.Nature communications · 2025Article
- Dissecting the genetic features and evolution ofmSystems · 2024Article
- Molecular characterization and antibiotic resistance ofFood science and biotechnology · 2024Article
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- Isolation and characterization of novel Staphylococcus aureus bacteriophage Hesat from dairy origin.Applied microbiology and biotechnology · 2024Article
- Transcription-replication interactions reveal principles of bacterial genome regulation.Research square · 2023Article
- Molecular Evolution and Genomic Insights into Community-Acquired Methicillin-Resistant Staphylococcus aureus Sequence Type 88.Microbiology spectrum · 2022Article
- Regulatory and Enterotoxin Gene Expression and Enterotoxins Production inInternational journal of molecular sciences · 2022Article
- Understanding the Mechanisms That Drive Phage Resistance in Staphylococci to Prevent Phage Therapy Failure.Viruses · 2022Review
- Phage satellites and their emerging applications in biotechnology.FEMS microbiology reviews · 2021Review
- Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands.mSphere · 2021Article
- Risk of Bacteriophage Therapeutics to Transfer Genetic Material and Contain Contaminants Beyond Endotoxins with Clinically Relevant Mitigation Strategies.Infection and drug resistance · 2021Article
- Characterisation and Molecular Analysis of an Unusual Chimeric Methicillin ResistantFrontiers in genetics · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus pathogenicity islands (SaPIs) are a type of mobile genetic element that play a significant role in the pathogenesis and virulence of this microorganism. SaPIs are integrated in the chromosome under the control of the master repressor Stl, but they can be horizontally transferred at a high frequency due to certain bacteriophages. Thus, a phage protein can bind to the SaPI Stl and induce the SaPI cycle, spreading the SaPI virulence factors to other bacterial populations. We report the dissemination mechanism of SaPIs mediated by endogenous prophages in S. aureus clinical strains. We reveal the induction of SaPIs by a co-resident prophage in seven clinically relevant strains, and we further study this mechanism in MW2, a community-acquired methicillin-resistant S. aureus strain that contains two bacteriophages (ɸSa2mw and ɸSa3mw) and one SaPI (SaPImw2) encoding for three enterotoxins (sec, sel and ear). ɸSa2mw was identified as responsible for SaPImw2 induction, and the specific phage derepressor protein DUF3113 was determined. The Stl-DUF3113 protein interaction was demonstrated, along with the existence of variants of this protein in S. aureus phages with different abilities to induce SaPI. Both Stl and DUF3113 are present in other Staphylococcus species, which indicates that this is a generalised mechanism.
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