ArticleScientific reports2018
An ultra-compact integrated system for brain activity recording and stimulation validated over cortical slow oscillations in vivo and in vitro.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
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- Enhanced Response of ZnO Nanorod-Based Flexible MEAs for Recording Ischemia-Induced Neural Activity in Acute Brain Slices.Nanomaterials (Basel, Switzerland) · 2025Article
- A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals.Advanced healthcare materials · 2025Article
- Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.Cellular and molecular life sciences : CMLS · 2023Article
- Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia.iScience · 2022Article
- Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo.Scientific reports · 2020Article
- Analysis and Model of Cortical Slow Waves Acquired with Optical Techniques.Methods and protocols · 2020Article
- Analysis Pipeline for Extracting Features of Cortical Slow Oscillations.Frontiers in systems neuroscience · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The understanding of brain processing requires monitoring and exogenous modulation of neuronal ensembles. To this end, it is critical to implement equipment that ideally provides highly accurate, low latency recording and stimulation capabilities, that is functional for different experimental preparations and that is highly compact and mobile. To address these requirements, we designed a small ultra-flexible multielectrode array and combined it with an ultra-compact electronic system. The device consists of a polyimide microelectrode array (8 µm thick and with electrodes measuring as low as 10 µm in diameter) connected to a miniaturized electronic board capable of amplifying, filtering and digitalizing neural signals and, in addition, of stimulating brain tissue. To evaluate the system, we recorded slow oscillations generated in the cerebral cortex network both from in vitro slices and from in vivo anesthetized animals, and we modulated the oscillatory pattern by means of electrical and visual stimulation. Finally, we established a preliminary closed-loop algorithm in vitro that exploits the low latency of the electronics (<0.5 ms), thus allowing monitoring and modulating emergent cortical activity in real time to a desired target oscillatory frequency.
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Registered trials
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