Evidence map›Paper›PMID 30425188›Full record

ArticleAging2018

Aging and drug discovery.

Daniela Bakula, Alexander M Aliper, Polina Mamoshina, Michael A Petr, Amanuel Teklu, Joseph A Baur, Judith Campisi, Collin Y Ewald, Anastasia Georgievskaya, Vadim N Gladyshev and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. G protein-coupled receptor digital twins for precision and personalized medicine.Computational and structural biotechnology journal · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. ENERGY SENSING PATHWAYS IN AGING AND CHRONIC LUNG DISEASE.Transactions of the American Clinical and Climatological Association · 2020
    Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Daniela BakulaCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Alexander M AliperPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA.
Polina MamoshinaPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA.
Michael A PetrCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Amanuel TekluCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Joseph A BaurInstitute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Judith CampisiBuck Institute for Research on Aging, Novato, CA 94945, USA.
Collin Y EwaldInstitute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute for Technology (ETH) Zürich, Switzerland.
Anastasia GeorgievskayaYouth Laboratories, Moscow, Russia.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
Olga KovalchukDepartment of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada.
Dudley W LammingDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
Martijn S LuijsterburgDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Alejandro Martín-MontalvoPancreatic Islet Development and Regeneration Unit/Laboratory of Aging Biology, Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain.
Stuart MaudsleyDepartment of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Garik V MkrtchyanCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Alexey MoskalevEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
S Jay OlshanskyDivision of Epidemiology and Biostatistics University of Illinois at Chicago School of Public Health, Chicago, IL 60612, USA.
Ivan V OzerovPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA.
Alexander PickettJuvenescence Limited, Douglas, Isle of Man, UK.
Michael RistowInstitute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute for Technology (ETH) Zürich, Switzerland.
Alex ZhavoronkovPharmaceutical Artificial Intelligence Department, Insilico Medicine, Inc., Baltimore, MD 20850, USA.
Morten Scheibye-KnudsenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Funding

The regulation of health and longevity by branched-chain amino acidsR01AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Dudley William Lamming · 2018 to 2026
$3.1M
Molecular Mechanisms of Rapamycin's Effects on Health and LongevityR01AG043483 · NIA · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2013 to 2017
$2.0M
Intervention in Progeria by Alterations in dietary macronutrient CompositionR21AG051974 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LAMMING, DUDLEY WILLIAM · 2017 to 2018
$409k
NIA NIH HHS R01 AG043483NIA NIH HHS R01 AG056771NIA NIH HHS R21 AG051974
6 · The paper itself

Abstract

Multiple interventions in the aging process have been discovered to extend the healthspan of model organisms. Both industry and academia are therefore exploring possible transformative molecules that target aging and age-associated diseases. In this overview, we summarize the presented talks and discussion points of the 5th Annual Aging and Drug Discovery Forum 2018 in Basel, Switzerland. Here academia and industry came together, to discuss the latest progress and issues in aging research. The meeting covered talks about the mechanistic cause of aging, how longevity signatures may be highly conserved, emerging biomarkers of aging, possible interventions in the aging process and the use of artificial intelligence for aging research and drug discovery. Importantly, a consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.

Indexed as

agingdrug discovery

Identifiers

PMID30425188
PMCPMC6286828

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.