ArticlemBio2018
Identifying and Predicting Novelty in Microbiome Studies.
Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- ResMicroDb: a comprehensive database and analysis platform for the human respiratory microbiome.Nucleic acids research · 2026Article
- Phylo-Spec: a phylogeny-fusion deep learning model advances microbiome status identification.mSystems · 2025Article
- KADAIF: an anomaly detection method for complex microbiome data.Bioinformatics (Oxford, England) · 2025Article
- Genomic potential for mercury biotransformation in marine sediments across marginal slope to hadal zone.Nature communications · 2025Article
- Novel order-level lineage of ammonia-oxidizing archaea widespread in marine and terrestrial environments.The ISME journal · 2024Article
- Exploring the role of indoor microbiome and environmental characteristics in rhinitis symptoms among university students.Frontiers in microbiomes · 2024Article
- Construction of a caries diagnosis model based on microbiome novelty score.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2023Article
- Airborne antibiotic resistome and human health risk in railway stations during COVID-19 pandemic.Environment international · 2023Article
- Single-cell Raman-activated sorting and cultivation (scRACS-Culture) for assessing and mining in situ phosphate-solubilizing microbes from nature.ISME communications · 2022Article
- Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies.Eco-Environment & Health · 2022Review
- Microbiomes in the Challenger Deep slope and bottom-axis sediments.Nature communications · 2022Article
- Elucidating the Beta-Diversity of the Microbiome: from Global Alignment to Local Alignment.mSystems · 2021Article
- A Scale-Free, Fully Connected Global Transition Network Underlies Known Microbiome Diversity.mSystems · 2021Article
- Microbiome Search Engine 2: a Platform for Taxonomic and Functional Search of Global Microbiomes on the Whole-Microbiome Level.mSystems · 2021Article
- HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes.Nucleic acids research · 2021Article
- Meta-Apo improves accuracy of 16S-amplicon-based prediction of microbiome function.BMC genomics · 2021Article
- Article
- Article
- Article
Corrections and comments
- Commented on by
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the expansion of microbiome sequencing globally, a key challenge is to relate new microbiome samples to the existing space of microbiome samples. Here, we present Microbiome Search Engine (MSE), which enables the rapid search of query microbiome samples against a large, well-curated reference microbiome database organized by taxonomic similarity at the whole-microbiome level. Tracking the microbiome novelty score (MNS) over 8 years of microbiome depositions based on searching in more than 100,000 global 16S rRNA gene amplicon samples, we detected that the structural novelty of human microbiomes is approaching saturation and likely bounded, whereas that in environmental habitats remains 5 times higher. Via the microbiome focus index (MFI), which is derived from the MNS and microbiome attention score (MAS), we objectively track and compare the structural-novelty and attracted-attention scores of individual microbiome samples and projects, and we predict future trends in the field. For example, marine and indoor environments and mother-baby interactions are likely to receive disproportionate additional attention based on recent trends. Therefore, MNS, MAS, and MFI are proposed "alt-metrics" for evaluating a microbiome project or prospective developments in the microbiome field, both of which are done in the context of existing microbiome big data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.