Evidence map›Paper›PMID 30425130›Full record

ArticlePediatrics2018

Risk Stratification of Febrile Infants ≤60 Days Old Without Routine Lumbar Puncture.

Paul L Aronson, Marie E Wang, Eugene D Shapiro, Samir S Shah, Adrienne G DePorre, Russell J McCulloh, Christopher M Pruitt, Sanyukta Desai, Lise E Nigrovic, Richard D Marble and 7 more

Abstract readMulticenter StudyVideo-Audio Media
In one paragraph

Article in Pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Development of an App to Facilitate Communication and Shared Decision-making With Parents of Febrile Infants ≤ 60 Days Old.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Analgesia for lumbar puncture in infants and children.Canadian family physician Medecin de famille canadien · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Paul L AronsonDepartments of Pediatrics and paul.aronson@yale.edu.
Marie E WangDivision of Pediatric Hospital Medicine, Lucile Packard Children's Hospital Stanford and Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, California.
Eugene D ShapiroDepartments of Pediatrics and.
Samir S ShahDivisions of Infectious Diseases and.
Adrienne G DePorreDivisions of Hospital Medicine and.
Russell J McCullohDivisions of Hospital Medicine and.
Christopher M PruittDivision of Pediatric Emergency Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Sanyukta DesaiHospital Medicine, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio.
Lise E NigrovicDivision of Emergency Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Harvard University, Boston, Massachusetts.
Richard D MarbleDivision of Emergency Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Rianna C LeazerDivision of Hospital Medicine, Department of Pediatrics, Children's Hospital of The King's Daughters, Norfolk, Virginia.
Sahar N RooholaminiDivision of Hospital Medicine, Seattle Children's Hospital and Department of Pediatrics, School of Medicine, University of Washington, Seattle, Washington.
Laura F SartoriDivision of Pediatric Emergency Medicine, Monroe Carell Jr Children's Hospital at Vanderbilt and Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville, Tennessee; and.
Fran BalamuthDivision of Emergency Medicine, and.
Christopher WollDepartments of Pediatrics and.
Mark I NeumanDivision of Emergency Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Harvard University, Boston, Massachusetts.
Febrile Young Infant Research Collaborative

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Conducting Child Health Care Research in Vulnerable PopulationsT32HD060554 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARKIN, SHARI, WILLIAMS, DEREK J. · 2009 to 2019
$3.8M
NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863NICHD NIH HHS T32 HD060554
6 · The paper itself

Abstract

: media-1vid110.1542/5840460609001PEDS-VA_2018-1879

methodsWe performed a case-control study of febrile infants ≤60 days old presenting to 1 of 9 emergency departments from 2011 to 2016. For each infant with IBI (defined as a blood [bacteremia] and/or CSF [bacterial meningitis] culture with growth of a pathogen), controls without IBI were matched by site and date of visit. Infants were excluded if they appeared ill or had a complex chronic condition or if data for any component of the Rochester or modified Philadelphia criteria were missing.

resultsOverall, 135 infants with IBI (118 [87.4%] with bacteremia without meningitis and 17 [12.6%] with bacterial meningitis) and 249 controls were included. The sensitivity of the modified Philadelphia criteria was higher than that of the Rochester criteria (91.9% vs 81.5%;

conclusionsThe modified Philadelphia criteria had high sensitivity for IBI without routine CSF testing, and all infants >28 days old with bacterial meningitis were classified as high risk. Because some infants with bacteremia were classified as low risk, infants discharged from the emergency department without CSF testing require close follow-up.

Indexed as

Emergency Service, HospitalBacteremiaFemaleFeverFollow-Up StudiesHumansIncidenceInfantInfant, NewbornMaleReproducibility of ResultsRetrospective StudiesRisk AssessmentROC CurveSpinal PunctureUnited States

Identifiers

PMID30425130
PMCPMC6317769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.