ArticleDiabetes2019
Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally.
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Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- MAFB in Pancreatic β-Cell Development and Dysfunction: Implications for Diabetes and Translational Applications.Biomolecules · 2026Review
- Review
- Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience.Diabetes · 2026Article
- Heat shock protein 72 (HSP72) modulates glucagon secretion via JNK inhibition in pancreatic α-cells.Diabetology international · 2026Article
- Epigenetic editing of marine medaka (Zoological research · 2026Article
- Microglia mediate the early-life programming of adult glucose control.Cell reports · 2025Article
- From stem cells to pancreatic β-cells: strategies, applications, and potential treatments for diabetes.Molecular and cellular biochemistry · 2025Review
- Animal models of haploinsufficiency revealed the isoform-specific role of GSK-3 in HFD-induced obesity and glucose intolerance.American journal of physiology. Cell physiology · 2024Article
- Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment.Current issues in molecular biology · 2024Review
- Microglia mediate the early-life programming of adult glucose control.bioRxiv : the preprint server for biology · 2024Article
- An Insight into Vital Genes Responsible for β-cell Formation.Advances in experimental medicine and biology · 2024Article
- Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators.Frontiers in cell and developmental biology · 2024Review
- Analysis of beta-cell maturity and mitochondrial morphology in juvenile non-human primates exposed to maternal Western-style diet during development.Frontiers in endocrinology · 2024Article
- Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity.JCI insight · 2023Article
- Pharmacological inhibition of human EZH2 can influence a regenerative β-like cell capacity with in vitro insulin release in pancreatic ductal cells.Clinical epigenetics · 2023Article
- MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas.Development (Cambridge, England) · 2023Article
- Epigenetic modulation of cell fate during pancreas development.Trends in developmental biology · 2023Article
- Pancreatic β-Cell Development and Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells.International journal of molecular sciences · 2022Review
- MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Holly A CyphertDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Emily M WalkerDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Yan HangDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Sangeeta DhawanDepartment of Translational Research and Cellular Therapeutics, Beckman Research Institute, City of Hope, Duarte, CA.
Rachana HaliyurDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Lauren BonatakisDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Dana AvrahamiEndocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Marcela BrissovaDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.
Klaus H KaestnerDepartment of Genetics and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.ORCID 0000-0002-1228-021X
Anil BhushanDiabetes Center, University of California, San Francisco, San Francisco, CA.
Alvin C PowersDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN.ORCID 0000-0003-1941-5786
Roland SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN roland.stein@vanderbilt.edu.ORCID 0000-0001-9192-8661
Vanderbilt University · USCity of Hope · USHadassah Medical Center · ILUniversity of California, San Francisco · USUniversity of Pennsylvania · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MThe Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6MTHREE-TIERED PREVENTION MODEL TO BETTER SERVE ALL STUDENP30HD015052 · NICHD · VANDERBILT UNIVERSITY · PI DYKENS, ELISABETH MAY · 1985 to 2014
$18.6MIntegrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MSupplement to Integrated Program for Human Pancreas Procurement and AnalysisUC4DK112232 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ATKINSON, MARK A., POWERS, ALVIN C · 2016 to 2020
$8.4MResearch Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MDiscovery of Pancreatic Signatures in Type 2 Diabetes MellitusR24DK106755 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAI, LONG, CAPRIOLI, RICHARD M · 2015 to 2019
$6.2MBLRD VA I01 BX000666NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NICHD NIH HHS P30 HD015052NICHD NIH HHS U54 HD083211NIDDK NIH HHS F32 DK102283NIDDK NIH HHS F32 DK109577NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK090570NIDDK NIH HHS R24 DK106755NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U24 DK098085NIDDK NIH HHS U2C DK059637NIDDK NIH HHS UC4 DK098085NIDDK NIH HHS UC4 DK104119NIDDK NIH HHS UC4 DK104211NIDDK NIH HHS UC4 DK108120NIDDK NIH HHS UC4 DK112232
Abstract
The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice. Moreover, mRNA expression of closely related and islet β-cell-enriched MAFA does not peak in humans until after 9 years of age. We show that the MAFA protein also is weakly produced within the juvenile human islet β-cell population and that
Indexed as
AnimalsCells, CulturedChromatin ImmunoprecipitationChromosomes, Artificial, BacterialDNA MethylationFemaleHumansInsulin-Secreting CellsIn Vitro TechniquesMafB Transcription FactorMaf Transcription Factors, LargeMiceMice, TransgenicPregnancyTryptophan HydroxylaseMafB Transcription FactorMaf Transcription Factors, LargeTryptophan Hydroxylase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.