Evidence map›Paper›PMID 30424663›Full record

ArticleThe Journal of the Acoustical Society of America2018

Dependence of inertial cavitation induced by high intensity focused ultrasound on transducer

Tatiana Khokhlova, Pavel Rosnitskiy, Christopher Hunter, Adam Maxwell, Wayne Kreider, Gail Ter Haar, Marcia Costa, Oleg Sapozhnikov, Vera Khokhlova

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of the Acoustical Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. xDDx: A Numerical Toolbox for Ultrasound Transducer Characterization and Design With Acoustic Holography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025
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  9. Dual-Mode 1-D Linear Ultrasound Array for Image-Guided Drug Delivery Enhancement Without Ultrasound Contrast Agents.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Article
  10. Article
  11. Article
  12. Aberration correction in abdominal histotripsy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
  13. The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
  14. Article
  15. Article
  16. Dual-Use Transducer for Ultrasound Imaging and Pulsed Focused Ultrasound Therapy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  17. Article
  18. Inertial Cavitation Behaviors Induced by Nonlinear Focused Ultrasound Pulses.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Tatiana KhokhlovaDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington 98125, USA.
Pavel RosnitskiyDepartment of Acoustics, Faculty of Physics, M.V. Lomonosov Moscow State University, Moscow 119991, Russia.
Christopher HunterCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105, USA.
Adam MaxwellDepartment of Urology, School of Medicine, University of Washington, Seattle, Washington 98195, USA.
Wayne KreiderCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105, USA.
Gail Ter HaarDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5PT, United Kingdom.
Marcia CostaDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5PT, United Kingdom.
Oleg SapozhnikovDepartment of Acoustics, Faculty of Physics, M.V. Lomonosov Moscow State University, Leninskie Gory, Moscow 119991, Russia.
Vera KhokhlovaDepartment of Acoustics, Faculty of Physics, M.V. Lomonosov Moscow State University, Leninskie Gory, Moscow 119991, Russia.
Lomonosov Moscow State University · RUUniversity of Washington · USInstitute of Cancer Research · GBJohns Hopkins University Applied Physics Laboratory · US

Funding

Nonlinear Acoustics in Calibration/Metrology of High Intensity Focused UltrasoundR01EB007643 · NIBIB · UNIVERSITY OF WASHINGTON · PI KHOKHLOVA, VERA · 2008 to 2020
$6.9M
Pulsed Focused Ultrasound (pFUS) exposures and devices for tissue permeabilization without contrast agentsR01EB023910 · NIBIB · UNIVERSITY OF WASHINGTON · PI KHOKHLOVA, TATIANA · 2017 to 2021
$2.3M
Noninvasive fragmentation of urinary calculi with focused ultrasound burstsK01DK104854 · NIDDK · UNIVERSITY OF WASHINGTON · PI MAXWELL, ADAM DOUGLAS · 2015 to 2019
$686k
Cancer Research UK 16464NIBIB NIH HHS R01 EB007643NIBIB NIH HHS R01 EB023910NIDDK NIH HHS K01 DK104854
6 · The paper itself

Abstract

Pulsed high intensity focused ultrasound was shown to enhance chemotherapeutic drug uptake in tumor tissue through inertial cavitation, which is commonly assumed to require peak rarefactional pressures to exceed a certain threshold. However, recent studies have indicated that inertial cavitation activity also correlates with the presence of shocks at the focus. The shock front amplitude and corresponding peak negative pressure (

Indexed as

Models, BiologicalTransducersUltrasonic WavesOscillometry

Identifiers

PMID30424663
PMCPMC6125138
OpenAlexW2891567096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.