Evidence map›Paper›PMID 30424580›Full record

ArticleJournal of developmental biology2018

Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice.

Rwik Sen, Sofia A Pezoa, Lomeli Carpio Shull, Laura Hernandez-Lagunas, Lee A Niswander, Kristin Bruk Artinger

Open access · goldAbstract read
In one paragraph

Article in Journal of developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 45 citations in OpenAlex.

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  10. Integrative analysis of histone acetyltransferase KAT2A in human cancer.Cancer biomarkers : section A of Disease markers · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rwik SenDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. rwik.sen@ucdenver.edu.
Sofia A PezoaCell Biology, Stem Cells, and Development Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Sofia.pezoa@ucdenver.edu.
Lomeli Carpio ShullDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Lomeli.Shull@ucdenver.edu.
Laura Hernandez-LagunasDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. ana-laura.Hernandez@ucdenver.edu.
Lee A NiswanderDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Lee.Niswander@colorado.edu.
Kristin Bruk ArtingerDepartment of Craniofacial Biology, School of Dental Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Kristin.Artinger@ucdenver.edu.ORCID 0000-0002-3003-6042
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · US

Funding

Function of chromatin modifiers in cranial neural crest developmentR01DE024034 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI ARTINGER, KRISTIN, NISWANDER, LEE A. · 2015 to 2019
$3.2M
NIDCR NIH HHS R01 DE024034NIH HHS R01DE024034
6 · The paper itself

Abstract

Cranial neural crest cells undergo cellular growth, patterning, and differentiation within the branchial arches to form cartilage and bone, resulting in a precise pattern of skeletal elements forming the craniofacial skeleton. However, it is unclear how cranial neural crest cells are regulated to give rise to the different shapes and sizes of the bone and cartilage. Epigenetic regulators are good candidates to be involved in this regulation, since they can exert both broad as well as precise control on pattern formation. Here, we investigated the role of the histone acetyltransferases Kat2a and Kat2b in craniofacial development using TALEN/CRISPR/Cas9 mutagenesis in zebrafish and the

Indexed as

cranial neural crest cellscraniofacial skeletonGCN5histone H3K9 acetylationPCAF

Identifiers

PMID30424580
PMCPMC6315545
OpenAlexW2901668015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.