ReviewInternational journal of molecular sciences2018
Impact of Machine Perfusion on Biliary Complications after Liver Transplantation.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- [Amatoxin poisoning with acute liver failure].Chirurgie (Heidelberg, Germany) · 2025Article
- A comparative study of argon plasma coagulation and electrosurgical knife on postoperative complications after curative resection for hepatocellular carcinoma.Langenbeck's archives of surgery · 2025Article
- Spectral Analysis of Extrahepatic Bile Ducts During Normothermic Liver Machine Perfusion.Bioengineering (Basel, Switzerland) · 2025Article
- Detecting biliary complications following liver transplantation with contrast-enhanced ultrasound.World journal of radiology · 2025Review
- Cholangiocyte Organoids: The New Frontier in Regenerative Medicine for the Study and Treatment of Cholangiopathies.Journal of clinical medicine · 2024Review
- Comprehensive bile acid pool analysis during ex-vivo liver perfusion in a porcine model of ischemia-reperfusion injury.Scientific reports · 2024Article
- Continuous Normothermic Machine Perfusion for Renovation of Extended Criteria Donor Livers Without Recooling in Liver Transplantation: A Pilot Experience.Frontiers in surgery · 2021Article
- Reassessment of Relevance and Predictive Value of Parameters Indicating Early Graft Dysfunction in Liver Transplantation: AST Is a Weak, but Bilirubin and INR Strong Predictors of Mortality.Frontiers in surgery · 2021Article
- Non-re-cooling implantation of marginal liver graft after machine perfusion: report of a case.Annals of translational medicine · 2020Article
- Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion.International journal of molecular sciences · 2020Review
- Selected liver grafts from donation after circulatory death can be safely used for retransplantation - a multicenter retrospective study.Transplant international : official journal of the European Society for Organ Transplantation · 2020Article
- Article
- Cell Interactions in Biliary Diseases: Clues from Pathophysiology and Repair Mechanisms to Foster Early Assessment.International journal of molecular sciences · 2019Review
- Hypothermic Oxygenated Machine Perfusion of Liver Grafts from Brain-Dead Donors.Scientific reports · 2019Article
- Mild hypothermia during the reperfusion phase protects mitochondrial bioenergetics against ischemia-reperfusion injury in an animal model of ex-vivo liver transplantation-an experimental study.International journal of medical sciences · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe in this review the different types of injuries caused to the biliary tree after liver transplantation. Furthermore, we explain underlying mechanisms and why oxygenated perfusion concepts could not only protect livers, but also repair high-risk grafts to prevent severe biliary complications and graft loss. Accordingly, we summarize experimental studies and clinical applications of machine liver perfusion with a focus on biliary complications after liver transplantation. Key points: (1) Acute inflammation with subsequent chronic ongoing liver inflammation and injury are the main triggers for cholangiocyte injury and biliary tree transformation, including non-anastomotic strictures; (2) Hypothermic oxygenated perfusion (HOPE) protects livers from initial oxidative injury at normothermic reperfusion after liver transplantation. This is a unique feature of a cold oxygenation approach, which is effective also end-ischemically, e.g., after cold storage, due to mitochondrial repair mechanisms. In contrast, normothermic oxygenated perfusion concepts protect by reducing cold ischemia, and are therefore most beneficial when applied instead of cold storage; (3) Due to less downstream activation of cholangiocytes, hypothermic oxygenated perfusion also significantly reduces the development of biliary strictures after liver transplantation.
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