ArticleMicromachines2018
Characterizing Longitudinal Changes in the Impedance Spectra of In-Vivo Peripheral Nerve Electrodes.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Stimulation-stability and preclinical bench testing of a new auditory nerve interface.Bioelectronic medicine · 2026Article
- Stimulation-Stability and Preclinical Bench Testing of a New Auditory Nerve Interface.Research square · 2026Article
- Electrochemical impedance spectroscopy for characterizing neural electrodes.Current opinion in electrochemistry · 2026Article
- Cortical potentials evoked by stimulation of cervical vagus vs. auricular nerve: a comparative, parametric study in nonhuman primates.bioRxiv : the preprint server for biology · 2025Article
- Quantifying physical degradation alongside recording and stimulation performance of 980 intracortical microelectrodes chronically implanted in three humans for 956-2130 days.Acta biomaterialia · 2025Article
- Evolution of spinal evoked compound action potential thresholds, visual motor thresholds, and impedances in a rodent spared nerve injury model.Frontiers in neuroscience · 2025Article
- Quantifying physical degradation alongside recording and stimulation performance of 980 intracortical microelectrodes chronically implanted in three humans for 956-2246 days.medRxiv : the preprint server for health sciences · 2024Article
- Article
- A universal model of electrochemical safety limitsFrontiers in neuroscience · 2022Article
- Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine.Bioelectronic medicine · 2021Article
- Electrochemical safety limits for clinical stimulation investigated using depth and strip electrodes in the pig brain.Journal of neural engineering · 2021Article
- Electrode Materials for Chronic Electrical Microstimulation.Advanced healthcare materials · 2021Review
- Development and characterization of a chronic implant mouse model for vagus nerve stimulation.eLife · 2021Article
- The Argo: a high channel count recording system for neural recording in vivo.Journal of neural engineering · 2021Article
- Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones.Frontiers in neuroscience · 2021Article
- Sharpened and Mechanically Durable Carbon Fiber Electrode Arrays for Neural Recording.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2021Article
- In Vitro/Ex Vivo Investigation of Modified Utah Electrode Array to Selectively Sense and Pace the Sub-Surface Cardiac His Bundle.ACS biomaterials science & engineering · 2020Article
- Evaluation of a conducting elastomeric composite material for intramuscular electrode application.Acta biomaterialia · 2020Article
- Classifying Intracortical Brain-Machine Interface Signal Disruptions Based on System Performance and Applicable Compensatory Strategies: A Review.Frontiers in neurorobotics · 2020Review
- Editorial for the Special Issue on Neural Electrodes: Design and Applications.Micromachines · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Characterizing the aging processes of electrodes in vivo is essential in order to elucidate the changes of the electrode⁻tissue interface and the device. However, commonly used impedance measurements at 1 kHz are insufficient for determining electrode viability, with measurements being prone to false positives. We implanted cohorts of five iridium oxide (IrOx) and six platinum (Pt) Utah arrays into the sciatic nerve of rats, and collected the electrochemical impedance spectroscopy (EIS) up to 12 weeks or until array failure. We developed a method to classify the shapes of the magnitude and phase spectra, and correlated the classifications to circuit models and electrochemical processes at the interface likely responsible. We found categories of EIS characteristic of iridium oxide tip metallization, platinum tip metallization, tip metal degradation, encapsulation degradation, and wire breakage in the lead. We also fitted the impedance spectra as features to a fine-Gaussian support vector machine (SVM) algorithm for both IrOx and Pt tipped arrays, with a prediction accuracy for categories of 95% and 99%, respectively. Together, this suggests that these simple and computationally efficient algorithms are sufficient to explain the majority of variance across a wide range of EIS data describing Utah arrays. These categories were assessed over time, providing insights into the degradation and failure mechanisms for both the electrode⁻tissue interface and wire bundle. Methods developed in this study will allow for a better understanding of how EIS can characterize the physical changes to electrodes in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.