ArticleMicromachines2018
Characterization of the Neuroinflammatory Response to Thiol-ene Shape Memory Polymer Coated Intracortical Microelectrodes.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed.
- Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance.Nature communications · 2025Article
- Systemically administered platelet-inspired nanoparticles to reduce inflammation surrounding intracortical microelectrodes.Biomaterials · 2025Article
- Hippocampal recording with a soft microelectrode array in a cranial window imaging scheme: a validation study.Scientific reports · 2024Article
- Corrigendum to "Platelets and Hemostatic Proteins are Co-Localized with Chronic Neuroinflammation Surrounding Implanted Intracortical Microelectrodes" [Acta Biomaterialia. Volume 166, August 2023, Pages 278-290].Acta biomaterialia · 2024Article
- Flexible neural probes: a review of the current advantages, drawbacks, and future demands.Journal of Zhejiang University. Science. B · 2024Review
- In Vivo Validation of a Mechanically Adaptive Microfluidic Intracortical Device as a Platform for Sustained Local Drug Delivery.Frontiers in biomaterials science · 2023Article
- Aberrant accumulation of age- and disease-associated factors following neural probe implantation in a mouse model of Alzheimer's disease.Journal of neural engineering · 2023Article
- Platelets and hemostatic proteins are co-localized with chronic neuroinflammation surrounding implanted intracortical microelectrodes.Acta biomaterialia · 2023Article
- Fabrication Methods and Chronic In Vivo Validation of Mechanically Adaptive Microfluidic Intracortical Devices.Micromachines · 2023Article
- Clickable Biomaterials for Modulating Neuroinflammation.International journal of molecular sciences · 2022Review
- Article
- Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Investigation of the Feasibility of Ventricular Delivery of Resveratrol to the Microelectrode Tissue Interface.Micromachines · 2021Article
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- Soft, Conductive, Brain-Like, Coatings at Tips of Microelectrodes Improve Electrical Stability under Chronic, In Vivo Conditions.Micromachines · 2021Article
- The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Recent advances in neural interfaces-Materials chemistry to clinical translation.MRS bulletin · 2020Article
- Evaluation of a conducting elastomeric composite material for intramuscular electrode application.Acta biomaterialia · 2020Article
- An Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite.Advanced healthcare materials · 2019Article
- Editorial for the Special Issue on Neural Electrodes: Design and Applications.Micromachines · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Thiol-ene based shape memory polymers (SMPs) have been developed for use as intracortical microelectrode substrates. The unique chemistry provides precise control over the mechanical and thermal glass-transition properties. As a result, SMP substrates are stiff at room temperature, allowing for insertion into the brain without buckling and subsequently soften in response to body temperatures, reducing the mechanical mismatch between device and tissue. Since the surface chemistry of the materials can contribute significantly to the ultimate biocompatibility, as a first step in the characterization of our SMPs, we sought to isolate the biological response to the implanted material surface without regards to the softening mechanics. To accomplish this, we tightly controlled for bulk stiffness by comparing bare silicon 'dummy' devices to thickness-matched silicon devices dip-coated with SMP. The neuroinflammatory response was evaluated after devices were implanted in the rat cortex for 2 or 16 weeks. We observed no differences in the markers tested at either time point, except that astrocytic scarring was significantly reduced for the dip-coated implants at 16 weeks. The surface properties of non-softening thiol-ene SMP substrates appeared to be equally-tolerated and just as suitable as silicon for neural implant substrates for applications such as intracortical microelectrodes, laying the groundwork for future softer devices to improve upon the prototype device performance presented here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.