ArticleMicromachines2018
A 3D-Printed Millifluidic Platform Enabling Bacterial Preconcentration and DNA Purification for Molecular Detection of Pathogens in Blood.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Comparison evaluation of bacterial DNA extraction methods for improved molecular diagnostic accuracy of sepsis-causing pathogens in clinical whole blood samples.Scientific reports · 2025Article
- Automated sepsis detection with vancomycin- and allantoin-polydopamine magnetic nanoparticles.Scientific reports · 2024Article
- Computer-aided engineering and additive manufacturing for bioreactors in tissue engineering: State of the art and perspectives.Biophysics reviews · 2023Review
- ABiosensors · 2022Article
- Vancomycin-conjugated polydopamine-coated magnetic nanoparticles for molecular diagnostics of Gram-positive bacteria in whole blood.Journal of nanobiotechnology · 2022Article
- Molecular detection of bacterial contamination in plasma using magnetic-based enrichment.Scientific reports · 2022Article
- Time-efficient fabrication method for 3D-printed microfluidic devices.Scientific reports · 2022Article
- Magnetic Bead Chain-Based Continuous-Flow DNA Extraction for Microfluidic PCR Detection ofMicromachines · 2021Article
- 3D-Printed Modular Microfluidic Device Enabling Preconcentrating Bacteria and Purifying Bacterial DNA in Blood for Improving the Sensitivity of Molecular Diagnostics.Sensors (Basel, Switzerland) · 2020Article
- Integrated Microfluidic Preconcentration and Nucleic Amplification System for Detection of Influenza A Virus H1N1 in Saliva.Micromachines · 2020Article
- 3D-printed Bioreactors forInternational journal of bioprinting · 2020Review
- Thermally stable and uniform DNA amplification with picosecond laser ablated graphene rapid thermal cycling device.Biosensors & bioelectronics · 2019Article
- Microfluidic Technologies for cfDNA Isolation and Analysis.Micromachines · 2019Review
- Editorial for the Special Issue on 3D Printed Microfluidic Devices.Micromachines · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Molecular detection of pathogens in clinical samples often requires pretreatment techniques, including immunomagnetic separation and magnetic silica-bead-based DNA purification to obtain the purified DNA of pathogens. These two techniques usually rely on handling small tubes containing a few millilitres of the sample and manual operation, implying that an automated system encompassing both techniques is needed for larger quantities of the samples. Here, we report a three-dimensional (3D)-printed millifluidic platform that enables bacterial preconcentration and genomic DNA (gDNA) purification for improving the molecular detection of target pathogens in blood samples. The device consists of two millichannels and one chamber, which can be used to preconcentrate pathogens bound to antibody-conjugated magnetic nanoparticles (Ab-MNPs) and subsequently extract gDNA using magnetic silica beads (MSBs) in a sequential manner. The platform was able to preconcentrate very low concentrations (1⁻1000 colony forming units (CFU)) of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.