Evidence map›Paper›PMID 30424361›Full record

ReviewMicromachines2018

Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals.

Bradley B Barth, Hsin-I Huang, Gianna E Hammer, Xiling Shen

Abstract readReview
In one paragraph

Review in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023
    Article
  3. Article
  4. Enlightening the frontiers of neurogastroenterology through optogenetics.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bradley B BarthDepartment of Biomedical Engineering, Duke University, Durham, NC 27710, USA. bradley.barth@duke.edu.ORCID 0000-0002-4344-7182
Hsin-I HuangDepartment of Immunology, Duke University, Durham, NC 27710, USA. hsin.i.huang@duke.edu.
Gianna E HammerDepartment of Immunology, Duke University, Durham, NC 27710, USA. gianna.hammer@duke.edu.
Xiling ShenDepartment of Biomedical Engineering, Duke University, Durham, NC 27710, USA. xiling.shen@duke.edu.

Funding

Defense Advanced Research Projects Agency N66001-15-2-4059National Institutes of Health OT2OD023849National Institutes of Health R35GM122465
6 · The paper itself

Abstract

Advanced electrode designs have made single-unit neural recordings commonplace in modern neuroscience research. However, single-unit resolution remains out of reach for the intrinsic neurons of the gastrointestinal system. Single-unit recordings of the enteric (gut) nervous system have been conducted in anesthetized animal models and excised tissue, but there is a large physiological gap between awake and anesthetized animals, particularly for the enteric nervous system. Here, we describe the opportunity for advancing enteric neuroscience offered by single-unit recording capabilities in awake animals. We highlight the primary challenges to microelectrodes in the gastrointestinal system including structural, physiological, and signal quality challenges, and we provide design criteria recommendations for enteric microelectrodes.

Indexed as

conscious recordingelectrode implantationenteric nervous systemin vivo electrophysiologymicroelectrodesneural interfaces

Identifiers

PMID30424361
PMCPMC6187697

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.