Evidence map›Paper›PMID 30424355›Full record

ReviewMicromachines2018

Techniques and Considerations in the Microfabrication of Parylene C Microelectromechanical Systems.

Jessica Ortigoza-Diaz, Kee Scholten, Christopher Larson, Angelica Cobo, Trevor Hudson, James Yoo, Alex Baldwin, Ahuva Weltman Hirschberg, Ellis Meng

Abstract readReview
In one paragraph

Review in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Review
  3. A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jessica Ortigoza-DiazDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. jortigoz@usc.edu.ORCID 0000-0003-1222-4506
Kee ScholtenDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. kscholte@usc.edu.ORCID 0000-0003-2650-1594
Christopher LarsonDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. larsonce@usc.edu.ORCID 0000-0002-7837-6847
Angelica CoboDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. acobo001@gmail.com.
Trevor HudsonDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. tqhudson@usc.edu.
James YooDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. james.yoo@usc.edu.ORCID 0000-0002-1086-5193
Alex BaldwinDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. abbaldwi@usc.edu.ORCID 0000-0002-2104-7778
Ahuva Weltman HirschbergDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. aweltman1@gmail.com.
Ellis MengDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. ellis.meng@usc.edu.

Funding

Defense Advanced Research Projects Agency HR0011-15-2-0006National Institutes of Health U01 NS099703National Science Foundation CBET-1343193National Science Foundation EFRI-1332394
6 · The paper itself

Abstract

Parylene C is a promising material for constructing flexible, biocompatible and corrosion-resistant microelectromechanical systems (MEMS) devices. Historically, Parylene C has been employed as an encapsulation material for medical implants, such as stents and pacemakers, due to its strong barrier properties and biocompatibility. In the past few decades, the adaptation of planar microfabrication processes to thin film Parylene C has encouraged its use as an insulator, structural and substrate material for MEMS and other microelectronic devices. However, Parylene C presents unique challenges during microfabrication and during use with liquids, especially for flexible, thin film electronic devices. In particular, the flexibility and low thermal budget of Parylene C require modification of the fabrication techniques inherited from silicon MEMS, and poor adhesion at Parylene-Parylene and Parylene-metal interfaces causes device failure under prolonged use in wet environments. Here, we discuss in detail the promises and challenges inherent to Parylene C and present our experience in developing thin-film Parylene MEMS devices.

Indexed as

MEMSmicrofabricationParylene

Identifiers

PMID30424355
PMCPMC6187609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.