Evidence map›Paper›PMID 30424342›Full record

ArticleMicromachines2018

Rapid Laser Manufacturing of Microfluidic Devices from Glass Substrates.

Krystian L Wlodarczyk, Richard M Carter, Amir Jahanbakhsh, Amiel A Lopes, Mark D Mackenzie, Robert R J Maier, Duncan P Hand, M Mercedes Maroto-Valer

Abstract read
In one paragraph

Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Targeted Cancer Therapy-on-A-Chip.Advanced healthcare materials · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Fabrication and Applications of Microfluidic Devices: A Review.International journal of molecular sciences · 2021
    Review
  18. Hemp-Based Microfluidics.Micromachines · 2021
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Krystian L WlodarczykResearch Centre for Carbon Solutions (RCCS), Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. K.L.Wlodarczyk@hw.ac.uk.ORCID 0000-0003-3604-9538
Richard M CarterInstitute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. R.M.Carter@hw.ac.uk.ORCID 0000-0002-8962-886X
Amir JahanbakhshResearch Centre for Carbon Solutions (RCCS), Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. A.Jahanbakhsh@hw.ac.uk.ORCID 0000-0002-8770-2296
Amiel A LopesInstitute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. aal1@hw.ac.uk.
Mark D MackenzieInstitute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. M.Mackenzie@hw.ac.uk.
Robert R J MaierInstitute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. R.R.J.Maier@hw.ac.uk.ORCID 0000-0002-5739-128X
Duncan P HandInstitute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. D.P.Hand@hw.ac.uk.
M Mercedes Maroto-ValerResearch Centre for Carbon Solutions (RCCS), Institute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK. M.Maroto-Valer@hw.ac.uk.

Funding

Engineering and Physical Sciences Research Council EP/K030884/1European Research Council 695070
6 · The paper itself

Abstract

Conventional manufacturing of microfluidic devices from glass substrates is a complex, multi-step process that involves different fabrication techniques and tools. Hence, it is time-consuming and expensive, in particular for the prototyping of microfluidic devices in low quantities. This article describes a laser-based process that enables the rapid manufacturing of enclosed micro-structures by laser micromachining and microwelding of two 1.1-mm-thick borosilicate glass plates. The fabrication process was carried out only with a picosecond laser (Trumpf TruMicro 5×50) that was used for: (a) the generation of microfluidic patterns on glass, (b) the drilling of inlet/outlet ports into the material, and (c) the bonding of two glass plates together in order to enclose the laser-generated microstructures. Using this manufacturing approach, a fully-functional microfluidic device can be fabricated in less than two hours. Initial fluid flow experiments proved that the laser-generated microstructures are completely sealed; thus, they show a potential use in many industrial and scientific areas. This includes geological and petroleum engineering research, where such microfluidic devices can be used to investigate single-phase and multi-phase flow of various fluids (such as brine, oil, and CO₂) in porous media.

Indexed as

enclosed microstructuresfluid displacementglasslaser materials processingmicrofluidic devicesporous mediaultrafast laser micromachiningultrafast laser welding

Identifiers

PMID30424342
PMCPMC6187741

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.