Evidence map›Paper›PMID 30424259›Full record

ArticleMicromachines2018

3D Printed Microfluidic Features Using Dose Control in X, Y, and Z Dimensions.

Michael J Beauchamp, Hua Gong, Adam T Woolley, Gregory P Nordin

Abstract read
In one paragraph

Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. 3D printed microfluidic devices with electrodes for electrochemical analysis.Analytical methods : advancing methods and applications · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. A Review of Microfluidic Experimental Designs for Nanoparticle Synthesis.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. 3D Printed Microfluidics.Annual review of analytical chemistry (Palo Alto, Calif.) · 2020
    Review
  17. Biocompatible PEGDA Resin for 3D Printing.ACS applied bio materials · 2020
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael J BeauchampDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. mikejbeau@byu.edu.
Hua GongDepartment of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA. gonghuabupt@gmail.com.
Adam T WoolleyDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. atw@byu.edu.
Gregory P NordinDepartment of Electrical and Computer Engineering, Brigham Young University, Provo, UT 84602, USA. nordin@byu.edu.ORCID 0000-0001-7241-5764

Funding

Phase-Changing Sacrificial Layer Microfluidics for Enhanced Protein AnalysisR01EB006124 · NIBIB · BRIGHAM YOUNG UNIVERSITY · PI WOOLLEY, ADAM THOMAS · 2006 to 2016
$3.1M
High Density 3D Printed Microfluidics With Open Source Resins for Biomedical ApplicationsR15GM123405 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI NORDIN, GREGORY P. · 2017 to 2023
$1.3M
National Institutes of Health R01EB006124 and R15GM123405-01A1NIBIB NIH HHS R01 EB006124NIGMS NIH HHS R15 GM123405
6 · The paper itself

Abstract

Interest has grown in recent years to leverage the possibilities offered by three-dimensional (3D) printing, such as rapid iterative changes; the ability to more fully use 3D device volume; and ease of fabrication, especially as it relates to the creation of complex microfluidic devices. A major shortcoming of most commercially available 3D printers is that their resolution is not sufficient to produce features that are truly microfluidic (<100 × 100 μm²). Here, we test a custom 3D printer for making ~30 μm scale positive and negative surface features, as well as positive and negative features within internal voids (i.e., microfluidic channels). We found that optical dosage control is essential for creating the smallest microfluidic features (~30 µm wide for ridges, ~20 µm wide for trenches), and that this resolution was achieved for a number of different exposure approaches. Additionally, we printed various microfluidic particle traps, showed capture of 25 µm diameter polymer beads, and iteratively improved the trap design. The rapid feedback allowed by 3D printing, as well as the ability to carefully control optical exposure conditions, should lead to new innovations in the types and sizes of devices that can be created for microfluidics.

Indexed as

3D printingmicrofluidicsparticle trapsstereolithography

Identifiers

PMID30424259
PMCPMC6082287

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.