ArticleMicromachines2018
Self-Assembled Mucin-Containing Microcarriers via Hard Templating on CaCO₃ Crystals.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Vaterite/Fucoidan Hybrid Microparticles: Fabrication, Loading of Lactoferrin, Structural Characteristics and Functional Properties.Marine drugs · 2025Article
- Serum Albumin in Nasal Drug Delivery Systems: Exploring the Role and Application.Pharmaceutics · 2024Review
- Influence of natural polysaccharides on the morphology and properties of hybrid vaterite microcrystals.Heliyon · 2024Article
- Nanoarchitectonics of Bactericidal Coatings Based on CaCOACS applied bio materials · 2024Article
- Incorporation of Pectin into Vaterite Microparticles Prevented Effects of Adsorbed Mucin on Neutrophil Activation.International journal of molecular sciences · 2023Article
- Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications.Pharmaceutics · 2023Review
- Activation of Neutrophils by Mucin-Vaterite Microparticles.International journal of molecular sciences · 2022Article
- Calcium carbonate vaterite particles for drug delivery: Advances and challenges.Materials today. Advances · 2022Review
- Modification of Surfaces with Vaterite CaCOMicromachines · 2022Review
- Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives.Nanomaterials (Basel, Switzerland) · 2021Review
- Advancing Discovery of Snail Mucins Function and Application.Frontiers in bioengineering and biotechnology · 2021Review
- Interactions of microorganisms with host mucins: a focus on Candida albicans.FEMS microbiology reviews · 2020Review
- Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics.Polymers · 2020Review
- Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering.Micromachines · 2020Review
- Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCOMicromachines · 2020Review
- Mucin adsorbed by E. coli can affect neutrophil activation in vitro.FEBS open bio · 2020Article
- Editorial for the Special Issue on Self-Assembly of Polymers.Micromachines · 2019Article
- Porous Alginate Scaffolds Assembled Using Vaterite CaCOMicromachines · 2019Review
- Development of Bioelectronic Devices Using Bionanohybrid Materials for Biocomputation System.Micromachines · 2019Review
- Internal Structure of Matrix-Type Multilayer Capsules Templated on Porous Vaterite CaCO₃ Crystals as Probed by Staining with a Fluorescence Dye.Micromachines · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porous vaterite crystals of CaCO₃ are extensively used for the fabrication of self-assembled polymer-based microparticles (capsules, beads, etc.) utilized for drug delivery and controlled release. The nature of the polymer used plays a crucial role and discovery of new perspective biopolymers is essential to assemble microparticles with desired characteristics, such as biocompatibility, drug loading efficiency/capacity, release rate, and stability. Glycoprotein mucin is tested here as a good candidate to assemble the microparticles because of high charge due to sialic acids, mucoadhesive properties, and a tendency to self-assemble, forming gels. Mucin loading into the crystals via co-synthesis is twice as effective as via adsorption into preformed crystals. Desialylated mucin has weaker binding to the crystals most probably due to electrostatic interactions between sialic acids and calcium ions on the crystal surface. Improved loading of low-molecular-weight inhibitor aprotinin into the mucin-containing crystals is demonstrated. Multilayer capsules (mucin/protamine)₃ have been made by the layer-by-layer self-assembly. Interestingly, the deposition of single mucin layers (mucin/water)₃ has also been proven, however, the capsules were unstable, most probably due to additional (to hydrogen bonding) electrostatic interactions in the case of the two polymers used. Finally, approaches to load biologically-active compounds (BACs) into the mucin-containing microparticles are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.