Evidence map›Paper›PMID 30424176›Full record

ReviewMicromachines2018

Nanostructure-Enabled and Macromolecule-Grafted Surfaces for Biomedical Applications.

Madeline Small, Addison Faglie, Alexandra J Craig, Martha Pieper, Vivian E Fernand Narcisse, Pierre F Neuenschwander, Shih-Feng Chou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Engineering Approaches to Prevent Blood Clotting from Medical Implants.Archives in biomedical engineering & biotechnology · 2019
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Madeline SmallDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA. msmall4@patriots.uttyler.edu.
Addison FaglieDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA. AFaglie@patriots.uttyler.edu.
Alexandra J CraigDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA. ACraig4@patriots.uttyler.edu.
Martha PieperDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA. mpieper@patriots.uttyler.edu.ORCID 0000-0002-1028-2844
Vivian E Fernand NarcisseDepartment of Chemistry and Physics, School of Arts and Sciences, LeTourneau University, Longview, TX 75607, USA. vivianfernandnarcisse@letu.edu.
Pierre F NeuenschwanderDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. Pierre.Neuenschwander@uthct.edu.
Shih-Feng ChouDepartment of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, 3900 University Blvd., Tyler, TX 75799, USA. schou@uttyler.edu.
The University of Texas at Tyler · USLeTourneau University · USThe University of Texas Health Science Center at Tyler · US

Funding

Office of Sponsor Research, The University of Texas at Tyler 21001323
6 · The paper itself

Abstract

Advances in nanotechnology and nanomaterials have enabled the development of functional biomaterials with surface properties that reduce the rate of the device rejection in injectable and implantable biomaterials. In addition, the surface of biomaterials can be functionalized with macromolecules for stimuli-responsive purposes to improve the efficacy and effectiveness in drug release applications. Furthermore, macromolecule-grafted surfaces exhibit a hierarchical nanostructure that mimics nanotextured surfaces for the promotion of cellular responses in tissue engineering. Owing to these unique properties, this review focuses on the grafting of macromolecules on the surfaces of various biomaterials (e.g., films, fibers, hydrogels, and etc.) to create nanostructure-enabled and macromolecule-grafted surfaces for biomedical applications, such as thrombosis prevention and wound healing. The macromolecule-modified surfaces can be treated as a functional device that either passively inhibits adverse effects from injectable and implantable devices or actively delivers biological agents that are locally based on proper stimulation. In this review, several methods are discussed to enable the surface of biomaterials to be used for further grafting of macromolecules. In addition, we review surface-modified films (coatings) and fibers with respect to several biomedical applications. Our review provides a scientific update on the current achievements and future trends of nanostructure-enabled and macromolecule-grafted surfaces in biomedical applications.

Indexed as

graftingmacromoleculessurfacesthrombosiswound healing

Identifiers

PMID30424176
PMCPMC6187347
OpenAlexW2804645054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.