Evidence map›Paper›PMID 30424153›Full record

ArticleMicromachines2018

Features in Microfluidic Paper-Based Devices Made by Laser Cutting: How Small Can They Be?

Md Almostasim Mahmud, Eric J M Blondeel, Moufeed Kaddoura, Brendan D MacDonald

Abstract read
In one paragraph

Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Microfluidic Organ-on-A-chip: A Guide to Biomaterial Choice and Fabrication.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Microfluidic Paper-based Device for Medicinal Diagnosis.Current topics in medicinal chemistry · 2022
    Article
  14. Glioma-on-a-Chip Models.Micromachines · 2021
    Article
  15. Microfluidic devices for detection of RNA viruses.Reviews in medical virology · 2021
    Review
  16. Article
  17. Article
  18. Review
  19. Paper-Based Sensors: Emerging Themes and Applications.Sensors (Basel, Switzerland) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Md Almostasim MahmudFaculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON L1H 7K4, Canada. md.mahmud@uoit.net.ORCID 0000-0001-9370-0951
Eric J M BlondeelExVivo Labs Inc., 3 Regina Street North, Suite A, Waterloo, ON N2J 2Z7, Canada. eric@exvivo.ca.
Moufeed KaddouraExVivo Labs Inc., 3 Regina Street North, Suite A, Waterloo, ON N2J 2Z7, Canada. moufeed@exvivo.ca.
Brendan D MacDonaldFaculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON L1H 7K4, Canada. brendan.macdonald@uoit.ca.ORCID 0000-0001-6619-1186

Funding

Natural Sciences and Engineering Research Council of Canada EGP 499478 2016
6 · The paper itself

Abstract

In this paper, we determine the smallest feature size that enables fluid flow in microfluidic paper-based analytical devices (µPADs) fabricated by laser cutting. The smallest feature sizes fabricated from five commercially available paper types: Whatman filter paper grade 50 (FP-50), Whatman 3MM Chr chromatography paper (3MM Chr), Whatman 1 Chr chromatography paper (1 Chr), Whatman regenerated cellulose membrane 55 (RC-55) and Amershan Protran 0.45 nitrocellulose membrane (NC), were 139 ± 8 µm, 130 ± 11 µm, 103 ± 12 µm, 45 ± 6 µm, and 24 ± 3 µm, respectively, as determined experimentally by successful fluid flow. We found that the fiber width of the paper correlates with the smallest feature size that has the capacity for fluid flow. We also investigated the flow speed of Allura red dye solution through small-scale channels fabricated from different paper types. We found that the flow speed is significantly slower through microscale features and confirmed the similar trends that were reported previously for millimeter-scale channels, namely that wider channels enable quicker flow speed.

Indexed as

compact µPADsmicrofluidicsminiaturizationpaper-based deviceswicking

Identifiers

PMID30424153
PMCPMC6187457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.