Evidence map›Paper›PMID 30424091›Full record

ArticleMicromachines2018

A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells.

Jingyi Xu, Shulei Chen, Dongyang Wang, Yue Jiang, Ming Hao, Guangyu Du, Dechun Ba, Qiao Lin, Qi Mei, Yingchao Ning and 2 more

Abstract read
In one paragraph

Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jingyi XuSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. 1700461@stu.neu.edu.cn.
Shulei ChenSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. 1710120@stu.neu.edu.cn.
Dongyang WangSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. wdysend@gmail.com.ORCID 0000-0002-0189-5884
Yue JiangSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. 1600460@stu.neu.edu.cn.
Ming HaoSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. 1500445@stu.neu.edu.cn.
Guangyu DuSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. gydu@mail.neu.edu.cn.ORCID 0000-0002-9925-3942
Dechun BaSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. dchba@mail.neu.edu.cn.
Qiao LinDepartment of Mechanical Engineering, Columbia University, New York, NY 10027, USA. qlin@columbia.edu.
Qi MeiDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. meiqi_tj@hust.edu.cn.
Yingchao NingShenyang Aeroengine Research Institute, Aviation Industry Corporation of China, Shenyang 110015, China. 1700459@stu.neu.edu.cn.
Da SuChina National Heavy Duty Truck Group Co., Ltd., Jinan 250101, China. suda@jszx.com.
Kun LiuSchool of Mechanical Engineering and Automation, Northeastern University, Shenyang 110819, China. meiqi_tj@hust.edu.cn.ORCID 0000-0003-0542-1739

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of microfluidic technology to manipulate cells or biological particles is becoming one of the rapidly growing areas, and various microarray trapping devices have recently been designed for high throughput single-cell analysis and manipulation. In this paper, we design a double-slit microfluidic chip for hydrodynamic cell trapping at the single-cell level, which maintains a high capture ability. The geometric effects on flow behaviour are investigated in detail for optimizing chip architecture, including the flow velocity, the fluid pressure, and the equivalent stress of cells. Based on the geometrical parameters optimized, the double-slit chip enhances the capture of HeLa cells and the drug experiment verifies the feasibility of the drug delivery.

Indexed as

cell capturedrug deliveryhydrodynamic cell trappingmicrofluidic chipsingle cell

Identifiers

PMID30424091
PMCPMC6187229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.