ArticleMicromachines2018
A Label Free Disposable Device for Rapid Isolation of Rare Tumor Cells from Blood by Ultrasounds.
Article in Micromachines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- A hybrid acoustofluidic device with Parafilm® that operates as a traditional bulk acoustic wave or flexural plate wave device.RSC advances · 2025Article
- Phononic-Crystal-Based Particle Sieving in Continuous Flow: Numerical Simulations.Micromachines · 2022Article
- Microfluidics geometries involved in effective blood plasma separation.Microfluidics and nanofluidics · 2022Review
- Influence of Hydrodynamics and Hematocrit on Ultrasound-Induced Blood Plasmapheresis.Micromachines · 2020Article
- Numerical Simulation of Boundary-Driven Acoustic Streaming in Microfluidic Channels with Circular Cross-Sections.Micromachines · 2020Article
- Cell Separations and Sorting.Analytical chemistry · 2020Review
- Leukocyte function assessed via serial microlitre sampling of peripheral blood from sepsis patients correlates with disease severity.Nature biomedical engineering · 2019Article
- Continuous Separation of Circulating Tumor Cells from Whole Blood Using a Slanted Weir Microfluidic Device.Cancers · 2019Article
- Advances in isolation and detection of circulating tumor cells based on microfluidics.Cancer biology & medicine · 2018Article
- Design and Parameter Study of Integrated Microfluidic Platform for CTC Isolation and Enquiry; A Numerical Approach.Biosensors · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of blood samples as liquid biopsy is a label-free method for cancer diagnosis that offers benefits over traditional invasive biopsy techniques. Cell sorting by acoustic waves offers a means to separate rare cells from blood samples based on their physical properties in a label-free, contactless and biocompatible manner. Herein, we describe a flow-through separation approach that provides an efficient separation of tumor cells (TCs) from white blood cells (WBCs) in a microfluidic device, "THINUS-Chip" (Thin-Ultrasonic-Separator-Chip), actuated by ultrasounds. We introduce for the first time the concept of plate acoustic waves (PAW) applied to acoustophoresis as a new strategy. It lies in the geometrical chip design: different to other microseparators based on either bulk acoustic waves (BAW) or surface waves (SAW, SSAW and tSAW), it allows the use of polymeric materials without restrictions in the frequency of work. We demonstrate its ability to perform high-throughput isolation of TCs from WBCs, allowing a recovery rate of 84% ± 8% of TCs with a purity higher than 80% and combined viability of 85% at a flow rate of 80 μL/min (4.8 mL/h). The THINUS-Chip performs cell fractionation with low-cost manufacturing processes, opening the door to possible easy printing fabrication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.