ArticleCells2018
The Heterochromatin Landscape in Migrating Cells and the Importance of H3K27me3 for Associated Transcriptome Alterations.
Article in Cells, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Histone Modifications in the Cell Cycle ofEpigenomes · 2026Review
- A side-by-side comparison of commercial CUT&RUN kits.Journal of biomolecular techniques : JBT · 2026Article
- Capillary constrictions prime cancer cell tumorigenicity through PIEZO1.Nature communications · 2025Article
- Review
- SLC25A19 drives colorectal cancer progression by regulating p53.Cancer medicine · 2024Article
- Histone methyltransferase SUV39H1 regulates the Golgi complex via the nuclear envelope-spanning LINC complex.PloS one · 2023Article
- Commercial ChIP-Seq Library Preparation Kits Performed Differently for Different Classes of Protein Targets.Journal of biomolecular techniques : JBT · 2022Article
- Constricted migration is associated with stable 3D genome structure differences in cancer cells.EMBO reports · 2022Article
- Confined migration induces heterochromatin formation and alters chromatin accessibility.iScience · 2022Article
- Article
- The histone variant macroH2A1.1 regulates RNA polymerase II-paused genes within defined chromatin interaction landscapes.Journal of cell science · 2022Article
- Review
- CTCF supports preferentially short lamina-associated domains.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Article
- Chromatin remodelers and lineage-specific factors interact to target enhancers to establish proneurosensory fate within otic ectoderm.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Increased Lamin B1 Levels Promote Cell Migration by Altering Perinuclear Actin Organization.Cells · 2020Article
- Dynamic changes in cis-regulatory occupancy by Six1 and its cooperative interactions with distinct cofactors drive lineage-specific gene expression programs during progressive differentiation of the auditory sensory epithelium.Nucleic acids research · 2020Article
- H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP.The Journal of clinical investigation · 2020Article
- Identification of Key Histone Modifications and Their Regulatory Regions on Gene Expression Level Changes in Chronic Myelogenous Leukemia.Frontiers in cell and developmental biology · 2020Article
- The Emerging Roles of Heterochromatin in Cell Migration.Frontiers in cell and developmental biology · 2020Review
- Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation.Molecular biology of the cell · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
H3K9me3, H3K27me3, and H4K20me1 are epigenetic markers associated with chromatin condensation and transcriptional repression. Previously, we found that migration of melanoma cells is associated with and dependent on global chromatin condensation that includes a global increase in these markers. Taken together with more recent reports by others suggests it is a general signature of migrating cells. Here, to learn about the function of these markers in migrating cells, we mapped them by ChIP-seq analysis. This analysis revealed that induction of migration leads to expansion of these markers along the genome and to an increased overlapping between them. Significantly, induction of migration led to a higher increase in H3K9me3 and H4K20me1 signals at repetitive elements than at protein-coding genes, while an opposite pattern was found for H3K27me3. Transcriptome analysis revealed 182 altered genes following induction of migration, of which 33% are dependent on H3K27me3 for these changes. H3K27me3 was also required to prevent changes in the expression of 501 other genes upon induction of migration. Taken together, our results suggest that heterochromatinization in migrating cells is global and not restricted to specific genomic loci and that H3K27me3 is a key component in executing a migration-specific transcriptional plan.
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