ReviewNutrients2018
Cow's Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- Effect of Maternal Diet on Any Necrotizing Enterocolitis in Neonates: A Randomized Double-Blind Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022Trial
- Microbiological and Immunological Markers in Milk and Infant Feces for Common Gastrointestinal Disorders: A Pilot Study.Nutrients · 2020Trial
- The human breast milk microbiome: a landscape review of its composition, origins, and impact on infant health.Archives of microbiology · 2026Review
- Cow's Milk Protein Allergy, a Systematic Review of Clinical Characteristics, Diagnosis, Management, and Economic Impact.Diseases (Basel, Switzerland) · 2026Review
- Allergic proctocolitis: Evaluation and management.Journal of food allergy · 2025Review
- Early-Life Events and the Prevalence of Gut-Brain Interaction Disorders in Children.Children (Basel, Switzerland) · 2025Article
- Linking IgE-mediated CMPA to functional gastrointestinal disorders.European journal of pediatrics · 2025Article
- The Burden of Cow's Milk Protein Allergy in the Pediatric Age: A Systematic Review of Costs and Challenges.Healthcare (Basel, Switzerland) · 2025Review
- The evolution of nutritional care in children with food allergies - With a focus on cow's milk allergy.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Review
- Serum eosinophil-derived neurotoxin: a new promising biomarker for cow's milk allergy diagnosis.Pediatric research · 2024Article
- Rome IV Clinical Criteria and Management of Functional Constipation: Indonesian Health Care Professionals' Perspective.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Review
- Characterizing camel milk constituents in the Sprague-Dawley rats' blood: A comparative profile with cow's milk attributes.Food science & nutrition · 2023Article
- Functional abdominal pain disorders in children in southern Anhui Province, China are related to academic stress rather than academic performance.BMC pediatrics · 2023Article
- Molecular Allergy Diagnostics in Children with Cow's Milk Allergy: Prediction of Oral Food Challenge Response in Clinical Practice.Journal of immunology research · 2023Article
- The Cow's Milk Related Symptom Score: The 2022 Update.Nutrients · 2022Article
- The Cow's Milk-Related Symptom Score (CoMiSSNutrients · 2022Review
- Cows' Milk Allergy-Associated Constipation: When to Look for It? A Narrative Review.Nutrients · 2022Review
- Article
- Recent advances in understanding the roles of the enteric nervous system.Faculty reviews · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role and prevalence of cow's milk protein allergy (CMA) in functional gastrointestinal disorders remains unclear. The aim of this review is to update knowledge on the relationship between CMA and functional abdominal pain disorders (FAPDs) in children. Cochrane Database and Pubmed were searched from inception using general and specific terms for CMA and functional gastrointestinal disorders. CMA is reported as a predisposing or coexisting factor in a wide range of functional gastrointestinal disorders in infants and children. Pathogenesis of both conditions is complex and multiple mechanisms including dysmotility and hypersensitivity might contribute to the clinical manifestations. Data supporting the possible role of food allergies in the pathogenesis of FAPDs are limited. CMA may predispose to early life inflammation and visceral hypersensitivity, which in turn might manifest as FAPDs. The diagnosis of either CMA or FAPDs and distinction between them is challenging because of nonspecific and overlapping symptoms. Lack of accurate allergy tests in non-IgE (immunoglobulin E) mediated cases is also problematic. Oral food challenge, following an elimination diet, should be performed to diagnose a suspected non-IgE CMA allergy in children with FAPDs. In the management of FAPDs, an elimination diet should be considered for a limited period to verify if the symptoms improve or resolve.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.