Evidence map›Paper›PMID 30423849›Full record

ArticleBiosensors2018

Andrey N Kuzmin, Artem Pliss, Alex Rzhevskii, Adrian Lita, Mioara Larion

Abstract read
In one paragraph

Article in Biosensors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. High Molecular Crowding in Repair Foci Surrounding DNA Breaks, Measured by Fluorescence Lifetime Imaging Microscopy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrey N KuzminAdvanced Cytometry Instrumentation Systems, LLC, Buffalo, NY 14203, USA. ankuzmin@buffalo.edu.
Artem PlissAdvanced Cytometry Instrumentation Systems, LLC, Buffalo, NY 14203, USA. lptacis@gmail.com.
Alex RzhevskiiThermo Fisher Scientific, Waltham, MA 02451, USA. ankuzmin@buffalo.edu.
Adrian LitaNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. adrian.lita@nih.gov.
Mioara LarionNeuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. mioara.larion@nih.gov.

Funding

Develop RAMAN imaging to visualize metabolism in cell lines and tissueZIABC011711 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LARION, MIOARA · 2016 to 2025
$3.3M
Novel single cell assay for quantitative analysis of cell heterogeneity by noninvasive probing of molecular composition of specific organelles in individual cellsR44GM116193 · NIGMS · ADVANCED CYTOMETRY INSTRUMENTATION SYS · PI KUZMIN, ANDREY · 2017 to 2018
$1.2M
Novel single cell assay for quantitative analysis of cell heterogeneity by noninvasive probing of molecular composition of specific organelles in individual cellsR43GM116193 · NIGMS · ADVANCED CYTOMETRY INSTRUMENTATION SYS · PI KUZMIN, ANDREY · 2016 to 2016
$148k
NIGMS NIH HHS R43 GM116193NIGMS NIH HHS R44 GM116193NIGMS NIH HHS R44GM116193
6 · The paper itself

Abstract

Raman microspectroscopy is a rapidly developing technique, which has an unparalleled potential for in situ proteomics, lipidomics, and metabolomics, due to its remarkable capability to analyze the molecular composition of live cells and single cellular organelles. However, the scope of Raman spectroscopy for bio-applications is limited by a lack of software tools for express-analysis of biomolecular composition based on Raman spectra. In this study, we have developed the first software toolbox for immediate analysis of intracellular Raman spectra using a powerful biomolecular component analysis (BCA) algorithm. Our software could be easily integrated with commercial Raman spectroscopy instrumentation, and serve for precise analysis of molecular content in major cellular organelles, including nucleoli, endoplasmic reticulum, Golgi apparatus, and mitochondria of either live or fixed cells. The proposed software may be applied in broad directions of cell science, and serve for further advancement and standardization of Raman spectroscopy.

Indexed as

AlgorithmsMicroscopyOrganellesSoftwareSpectrum Analysis, Ramanbiomolecular analysismicroscopyRaman spectrometrysingle cell assay

Identifiers

PMID30423849
PMCPMC6316203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.