ArticleThe EMBO journal1988
Tissue-specific expression of a vimentin--desmin hybrid gene in transgenic mice.
Article in The EMBO journal, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Lens Biology and Biochemistry.Progress in molecular biology and translational science · 2015Review
- Demyelination and axonal dystrophy in alpha A-crystallin transgenic mice.International journal of experimental pathology · 2000Article
- Peripheral neuropathy in mice transgenic for a human MDR3 P-glycoprotein mini-gene.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin.The Journal of cell biology · 1994Article
- Assembly of amino-terminally deleted desmin in vimentin-free cells.The Journal of cell biology · 1990Article
- Hair-specific expression of chloramphenicol acetyltransferase in transgenic mice under the control of an ultra-high-sulfur keratin promoter.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation.The Journal of cell biology · 1989Article
- Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells.The Journal of cell biology · 1989Article
- Enhancer elements directing cell-type-specific expression of cytokeratin genes and changes of the epithelial cytoskeleton by transfections of hybrid cytokeratin genes.The EMBO journal · 1989Article
- SV40 large T antigen-induced inhibition of terminal differentiation of primary skeletal muscle cells is associated with a block in the expression of MyoD and myogenin.Molecular biology reportsArticle
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have introduced a hybrid gene, pVVim2, composed of the 5' region of the hamster vimentin gene encoding the head and rod domain of vimentin and the 3' region of the hamster desmin gene encoding the tail domain of desmin, into the germ line of mice by pronuclear injection. RNA and protein analysis of mice transgenic for this construct showed that the pVVim2 gene was expressed at high levels in a developmental and tissue-specific manner. This indicates that the vimentin-derived segment of the fusion gene contains all the regulatory elements required for vimentin-specific expression. Immunohistochemical staining of fibroblast cultures derived from the transgenic mice with antibodies specific for vimentin and desmin demonstrated that the pVVim2 protein is assembled into filaments that co-localize with the endogenous vimentin filaments. The expression of pVVim2 protein in mesenchymal cells does not interfere with the function of vimentin in these cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.