Evidence map›Paper›PMID 30423760›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2019

Electrospun nanofibrous thermoplastic polyurethane/poly(glycerol sebacate) hybrid scaffolds for vocal fold tissue engineering applications.

Lin Jiang, Yongchao Jiang, Jeanna Stiadle, Xiaofeng Wang, Lixia Wang, Qian Li, Changyu Shen, Susan L Thibeault, Lih-Sheng Turng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Different methods of synthesizing poly(glycerol sebacate) (PGS): A review.Frontiers in bioengineering and biotechnology · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Biomimetic Hybrid Systems for Tissue Engineering.Biomimetics (Basel, Switzerland) · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lin JiangNational Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, China; School of Material Science and Engineering, Zhengzhou University, Zhengzhou, China; Department of Mechanical Engineering, University of Wisconsin-Madison, WI, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, WI, USA.
Yongchao JiangNational Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, China; Department of Mechanical Engineering, University of Wisconsin-Madison, WI, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, WI, USA.
Jeanna StiadleDepartments of Surgery, University of Wisconsin-Madison, WI, USA.
Xiaofeng WangNational Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, China.
Lixia WangNational Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, China.
Qian LiNational Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, China. Electronic address: qianli@zzu.edu.cn.
Changyu ShenNational Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou, China.
Susan L ThibeaultDepartments of Surgery, University of Wisconsin-Madison, WI, USA.
Lih-Sheng TurngDepartment of Mechanical Engineering, University of Wisconsin-Madison, WI, USA; Wisconsin Institute for Discovery, University of Wisconsin-Madison, WI, USA. Electronic address: turng@engr.wisc.edu.
University of Wisconsin–Madison · USZhengzhou University · CN

Funding

Engineering the Vocal Fold MucosaR01DC004336 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2000 to 2026
$14.6M
NIDCD NIH HHS R01 DC004336
6 · The paper itself

Abstract

Vocal fold tissue engineering requires biomimetic scaffolds with an appropriate matrix stiffness closely matching that of the natural vocal folds to maintain function. Traditionally, poly(ɛ‑caprolactone) (PCL) and thermoplastic polyurethane (TPU) have been employed as the primary matrix materials for vocal fold electrospun scaffolds. However, not all of the scaffolds fabricated thus far matched the human vocal fold tissues. Poly(glycerol sebacate) (PGS) is a non-cytotoxic and biodegradable soft elastomer that has shown promising results for soft tissue engineering applications. However, no work has been done to employ this biomaterial to construct vocal fold scaffolds. In this study, PGS has been synthesized and blended with thermoplastic polyurethane (TPU) to produce vocal fold scaffolds with improved hydrophilicity and compliance by electrospinning. The resulting scaffolds were found to have mechanical properties mimicking those of the vocal fold lamina propria extracellular matrix (ECM). An unusual leaf-like structure was obtained when using 1,1,1,3,3,3‑hexafluoroisopropanol (HFIP) as the solvent. Other suitable fibrous scaffolds were also obtained when using acetic acid and 2,2,2‑trifluoroethanol (TFE) as binary solvents. A biological evaluation of these TPU/PGS scaffolds showed better cell spreading and significantly improved cell proliferation as compared to TPU-only scaffolds (p < 0.01), thereby suggesting potential applications for vocal fold tissue engineering.

Indexed as

TemperatureAnimalsCalorimetry, Differential ScanningCell DeathCell ProliferationCytoskeletonDecanoatesGlycerolMiceNanofibersNIH 3T3 CellsPlasticsPolymersPolyurethanesPorositySpectroscopy, Fourier Transform InfraredDecanoatesGlycerolPlasticspoly(glycerol-sebacate)PolymersPolyurethanesWater

Identifiers

PMID30423760
PMCPMC6390294
OpenAlexW2895298071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.