Evidence map›Paper›PMID 30423313›Full record

ArticleBiochemical pharmacology2019

Isoform-specific therapeutic control of sulfonation in humans.

Ian Cook, Ting Wang, Thomas S Leyh

Abstract read
In one paragraph

Article in Biochemical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. The Human UGT2B7 Nanodisc.Drug metabolism and disposition: the biological fate of chemicals · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ian CookDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461-1926, United States.
Ting WangDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461-1926, United States.
Thomas S LeyhDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461-1926, United States. Electronic address: tom.leyh@einstein.yu.edu.
Albert Einstein College of Medicine · US

Funding

The Study of Human Sulfuryl-Transfer BiologyR35GM127144 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LEYH, THOMAS S. · 2018 to 2022
$2.3M
Sulfotransferase Specificity and the Development of Sulfation Resistant CompoundsR01GM106158 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LEYH, THOMAS S. · 2014 to 2016
$1.1M
Allosteric Regulation of Human Cytosolic SulfotransferasesR01GM121849 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LEYH, THOMAS S. · 2017 to 2018
$888k
NIGMS NIH HHS R01 GM106158NIGMS NIH HHS R01 GM121849NIGMS NIH HHS R35 GM127144
6 · The paper itself

Abstract

The activities of hundreds, perhaps thousands, of metabolites are regulated by human cytosolic sulfotransferases (SULTs) - a 13-member family of disease relevant enzymes that catalyze transfer of the sulfuryl moiety (-SO

Indexed as

AcetaminophenAllosteric SiteAnti-Inflammatory Agents, Non-SteroidalArylsulfotransferaseBinding SitesDehydroepiandrosteroneDrug InteractionsHumansIsoenzymesMagnetic Resonance SpectroscopyMefenamic AcidSulfotransferasesAcetaminophenalcohol sulfotransferaseAnti-Inflammatory Agents, Non-SteroidalArylsulfotransferaseDehydroepiandrosteroneIsoenzymesMefenamic AcidSulfotransferasesSULT1A1 protein, humanAcetaminophenAllostericDrug-drug interactionInhibitionLXRMefenamic acidMetabolismNMRNSAIDOpioidPainPharmacokineticsRegulationSulfotransferaseToxicity

Identifiers

PMID30423313
PMCPMC6625639
OpenAlexW2899635812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.