Evidence map›Paper›PMID 30423197›Full record

Observational studyJournal of the American Geriatrics Society2019

Hospital-Associated Complications of Older People: A Proposed Multicomponent Outcome for Acute Care.

Alison M Mudge, Prue McRae, Ruth E Hubbard, Nancye M Peel, Wen Kwang Lim, Adrian G Barnett, Sharon K Inouye

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Geriatrics Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Admission avoidance hospital at home.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Exercise for acutely hospitalised older medical patients.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
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  5. Article
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  9. What's in a Number: Do Transfer Rates Reflect Nursing Home Quality?Journal of the American Geriatrics Society · 2026
    Article
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  17. Effect of hospital-acquired complications on hospital length of stay and cost for older adults after a hip fracture in New South Wales, Australia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  18. What Is Important to Older People When Accessing Urgent Health Care: Key Considerations and Recommendations From Consumer Consultations.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alison M MudgeInternal Medicine Research Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.ORCID 0000-0002-0242-2165
Prue McRaeInternal Medicine Research Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Ruth E HubbardCentre for Research in Geriatric Medicine, University of Queensland, Brisbane, Queensland, Australian.
Nancye M PeelCentre for Research in Geriatric Medicine, University of Queensland, Brisbane, Queensland, Australian.ORCID 0000-0002-3038-8881
Wen Kwang LimRoyal Melbourne Hospital, Melbourne, Victoria, Australia.
Adrian G BarnettInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Sharon K InouyeInstitute for Aging Research, Hebrew Senior Life, Harvard Medical School, Boston, Massachusetts.

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI DICKERSON, BRADFORD C · 2010 to 2022
$26.7M
Development and Validation of a Delirium Severity ToolkitR01AG044518 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K., JONES, RICHARD N · 2014 to 2024
$7.3M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
K07 Leadership GrantK07AG041835 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2013 to 2017
$656k
NIA NIH HHS K07 AG041835NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG044518NIA NIH HHS R24 AG054259
6 · The paper itself

Abstract

objectivesTo propose a new multicomponent measure of hospital-associated complications of older people (HAC-OP) and evaluate its validity in a large hospital sample.

designObservational study using baseline (pre-intervention) data from the Collaboration for Hospitalised Elders Reducing the Impact of Stays in Hospital cluster randomized controlled trial.

settingAcute medical and surgical wards in 4 hospitals in Queensland, Australia.

participantsIndividuals aged 65 and older (mean age 76, 48% female) with a hospital stay of 72 hours or longer (N=434). MEASUREMENTS: We developed a multicomponent measure including 5 well-recognized hospital-associated complications of older people: hospital-associated delirium, functional decline, incontinence, falls, and pressure injuries. To evaluate construct validity, we examined associations with common risk factors (aged ≥75, functional impairment, cognitive impairment, history of falls). To evaluate predictive validity, we examined the association between length of stay, facility discharge, and 6-month mortality and any HAC-OP and total number of HAC-OP.

resultsOverall, 192 (44%) participants had 1 or more HAC-OP during their admission. Any HAC-OP was strongly associated with the proposed shared risk factors, and there was a strong and graded association between HAC-OP and length of stay (9.1±7.4 days for any HAC-OP vs 6.8 ±4.1 days with none, p < .001), facility discharge (59/192 (31%) vs 27/242 (11%), p < .001) and 6-month mortality (26/192 (14%) vs 17/242 (7%), p = .02).

conclusionThis study provides evidence of construct and predictive validity of the proposed measure of HAC-OP as a potential outcome measure for research investigating and improving hospital care of older people. J Am Geriatr Soc 67:352-356, 2019.

Indexed as

AgedAged, 80 and overCritical CareFemaleGeriatric AssessmentHospitalsHumansIatrogenic DiseaseLength of StayMaleOutcome Assessment, Health CareQueenslandReproducibility of Resultsdeliriumfunctional declinegeriatric syndromehospitalizationincontinence

Identifiers

PMID30423197
PMCPMC6367036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.