ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
NFκB Regulates Muscle Development and Mitochondrial Function.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Comparative Transcriptomic Analysis Between High- and Low-Growth-Rate Meat-Type Rabbits Reveals Key Pathways Associated with Muscle Development.Animals : an open access journal from MDPI · 2025Article
- Chronic treatment of old mice with AICAR reverses age-related changes in exercise performance and skeletal muscle gene expression.FASEB bioAdvances · 2025Article
- Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress.Frontiers in neuroscience · 2025Review
- Molecular hallmarks of ageing in amyotrophic lateral sclerosis.Cellular and molecular life sciences : CMLS · 2024Review
- Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease.Cell reports · 2023Article
- Mitochondrial dysfunction: roles in skeletal muscle atrophy.Journal of translational medicine · 2023Review
- Weight bearing training alleviates muscle atrophy and pyroptosis of middle-aged rats.Frontiers in endocrinology · 2023Article
- Boosting Mitochondrial Potential: An Imperative Therapeutic Intervention in Amyotrophic Lateral Sclerosis.Current neuropharmacology · 2023Review
- San Antonio Nathan Shock Center: your one-stop shop for aging research.GeroScience · 2021Article
- MicroRNA-33-5p inhibits cholesterol efflux in vascular endothelial cells by regulating citrate synthase and ATP-binding cassette transporter A1.BMC cardiovascular disorders · 2021Article
- The Impact of Melatonin and NLRP3 Inflammasome on the Expression of microRNAs in Aged Muscle.Antioxidants (Basel, Switzerland) · 2021Article
- Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective.Brain : a journal of neurology · 2020Review
- Review
- Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading.Cellular and molecular life sciences : CMLS · 2019Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Nuclear factor (NF)κB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated in the regulation of metabolic processes and tissue mass, yet its affects on mitochondrial function in this tissue are unclear. To investigate the role of NFκB on mitochondrial function and its relationship with muscle mass across the life span, we study a mouse model with muscle-specific NFκB suppression (muscle-specific IκBα super-repressor [MISR] mice). In wild-type mice, there was a natural decline in muscle mass with aging that was accompanied by decreased mitochondrial function and mRNA expression of electron transport chain subunits. NFκB inactivation downregulated expression of PPARGC1A, and upregulated TFEB and PPARGC1B. NFκB inactivation also decreased gastrocnemius (but not soleus) muscle mass in early life (1-6 months old). Lower oxygen consumption rates occurred in gastrocnemius and soleus muscles from young MISR mice, whereas soleus (but not gastrocnemius) muscles from old MISR mice displayed increased oxygen consumption compared to age-matched controls. We conclude that the NFκB pathway plays an important role in muscle development and growth. The extent to which NFκB suppression alters mitochondrial function is age dependent and muscle specific. Finally, mitochondrial function and muscle mass are tightly associated in both genotypes and across the life span.
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Registered trials
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