Trial reportPloS one2018
Tick-borne encephalitis: A 43-year summary of epidemiological and clinical data from Latvia (1973 to 2016).
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The long-term efficacy of tick-borne encephalitis vaccines available in Europe - a systematic review.BMC infectious diseases · 2023Pooled it
- Article
- Long-Term Outcomes in Adult Patients with Tick-Borne Encephalitis in Latvia.Pathogens (Basel, Switzerland) · 2026Article
- Distribution and Genotypic Landscape of Tick-Borne Encephalitis Virus in Ticks from Latvia from 2019 to 2023.Pathogens (Basel, Switzerland) · 2025Article
- Tick-borne encephalitis virus subtypes: mono- and mixed infection in specific and non-specific ticks.Frontiers in cellular and infection microbiology · 2025Article
- Incidence of tick-borne encephalitis (TBE) in the pediatric population at the University Hospitals of Strasbourg (HUS) and characterization of confirmed cases.Journal of neurovirology · 2024Article
- Tick-borne encephalitis infections without CNS involvement: An observational study in Latvia, 2007-2022.PloS one · 2024Observational
- Tick-Borne Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023Article
- Article
- Recommendations to Improve Tick-Borne Encephalitis Surveillance and Vaccine Uptake in Europe.Microorganisms · 2022Review
- Article
- Incidence of Tick-Borne Encephalitis during the COVID-19 Pandemic in Selected European Countries.Journal of clinical medicine · 2022Article
- Burden of Tick-Borne Encephalitis, Sweden.Emerging infectious diseases · 2022Article
- Microbiological Outcomes Associated With Low Leukocyte Counts in Cerebrospinal Fluid.Open forum infectious diseases · 2021Article
- Large-scale countrywide screening for tick-borne pathogens in field-collected ticks in Latvia during 2017-2019.Parasites & vectors · 2020Article
- Patients with breakthrough tick-borne encephalitis suffer a more severe clinical course and display extensive magnetic resonance imaging changes.European journal of neurology · 2020Article
- Tick-Borne Encephalitis Virus Infection Alters the Sialome ofFrontiers in cellular and infection microbiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of tick-borne encephalitis (TBE) varies significantly over time. To better understand the annual incidence of all TBE cases in Latvia we investigated the disease burden in the country from 1973-2016 using several available sources and case definitions.
methodsWe identified cases of TBE from an electronic database (maintained by the Centre for Disease Prevention and Control of Latvia [CDPC]) by the use of ICD-10 diagnosis codes for TBE (A84; A84.0; A84.1; A84.8; A84.9). In addition, previously unreported TBE cases were found by review of TBE diagnoses according to ICD-10 codes in four hospital databases.
resultsFrom 1973 to 2016 a total of 15,193 TBE cases were reported to the CDPC, 2,819 of which were reported from January 2007 through December 2016, additionally for this time period, 104 cases were identified via hospital survey. From all 2,923 reported cases (2007-2016), 1,973 met TBE case definition criteria and were included in the TBE study analysis. The highest average 10 year incidence was observed from 1990-1999 (27.9 cases per 100,000; range 4.6-53.0), however, the average 10-year incidence from 2007-2016 using officially adopted TBE case definition was 9.6 cases per 100,000 (range 5.8-14.6). For this 10-year time period most cases were adults (95.1%) and male (52.2%). The most common clinical form of TBE was meningitis (90.6%). A tick bite prior to TBE onset was reported in 60.6% of TBE cases and 98.2% of cases were not vaccinated against TBE.
conclusionThe data demonstrate that the incidence of TBE varies by about one third based on the case definition used. TBE occurs almost entirely in the unvaccinated population. Regular TBE awareness campaigns could encourage the population in Latvia to use protective measures to further control TBE in the country, either via vaccination or tick avoidance.
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