Evidence map›Paper›PMID 30422981›Full record

ArticlePLoS neglected tropical diseases2018

Rabies post-exposure prophylaxis started during or after travel: A GeoSentinel analysis.

Philippe Gautret, Kristina M Angelo, Hilmir Asgeirsson, David G Lalloo, Marc Shaw, Eli Schwartz, Michael Libman, Kevin C Kain, Watcharapong Piyaphanee, Holly Murphy and 11 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
In one paragraph

Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04961983 (A Comprehensive Travel Health Education Improving Attitude, Subjective Norm, Perceived Behavioral Control, Role Identity, Actual Behavioral Control, and Intention to Provide Travel Health Information of Tour Guides in Bali), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04961983 naunknown statusnot on this mapstarted 2021, after this paper: background citation

A Comprehensive Travel Health Education Improving Attitude, Subjective Norm, Perceived Behavioral Control, Role Identity, Actual Behavioral Control, and Intention to Provide Travel Health Information of Tour Guides in Bali

TypeinterventionalSponsorUdayana UniversityRan2021 to 2022Enrolled152ConditionsBehavior, Health, Travel-Related IllnessArmsComprehensive Travel Health Education Model
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. A SynB1-conjugated antibody cocktail crosses the blood-brain barrier to produce a therapeutic effect on rabies.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Travel-Related Diagnoses Among U.S. Nonmigrant Travelers or Migrants Presenting to U.S. GeoSentinel Sites - GeoSentinel Network, 2012-2021.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Vaccines and Senior Travellers.Frontiers in aging · 2021
    Review
  12. GeoSentinel: past, present and future†.Journal of travel medicine · 2020
    Review
  13. Article
  14. Prevention of human rabies: a challenge for the European Union and the European Economic Area.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 12 countries.

Philippe GautretInstitut Méditerranée Infection, Aix-Marseille University, Marseille, France.
Kristina M AngeloDivision of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
Hilmir AsgeirssonDepartment of Infectious Diseases, Karolinska University Hospital, and Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
David G LallooDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Marc ShawPublic Health and Tropical Medicine Department, James Cook University, Townsville, Australia, and WORLDWISE Travellers Health Centres of New Zealand.
Eli SchwartzThe Center of Geographical Medicine, Sheba Medical Center, Tel HaShomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Michael LibmanJ.D. MacLean Centre for Tropical Diseases, McGill University, Montreal, Canada.
Kevin C KainTropical Disease Unit, UHN-Toronto General Hospital, University of Toronto, Toronto, Canada.
Watcharapong PiyaphaneeDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Holly MurphyCIWEC Hospital and Travel Medicine Center, Kathmandu, Nepal.
Karin LederSchool of Epidemiology and Preventive Medicine, Monash University, and Victorian Infectious Disease Service, Royal Melbourne Hospital at the Doherty Institute for Infection and Immunity, Melbourne, Australia.
Jean VinceletteClinique Santé-voyage, Fondation du CHUM, Université de Montréal, Montreal, Canada.
Mogens JenseniusDepartment of Infectious Diseases - Oslo University Hospital, Oslo, Norway.
Jesse WaggonerDepartment of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Daniel LeungDivision of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
Sarah BorweinTravelSafe Medical Centre - Central Health Medical Practice, Hong Kong, China.
Lucille BlumbergNational Institute for Communicable Diseases, South Africa.
Patricia SchlagenhaufUniversity of Zürich Centre for Travel Medicine, WHO Collaborating Centre for Travellers' Health, Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Switzerland.
Elizabeth D BarnettMaxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, and Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, United States of America.
Davidson H HamerDepartment of Global Health, Boston University School of Public Health and Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America.
GeoSentinel Global Surveillance Network
Boston University · USCenters for Disease Control and Prevention · USCivil Service Hospital · NPEmory University · USKarolinska Institutet · SELiverpool School of Tropical Medicine · GBMahidol Oxford Tropical Medicine Research Unit · THMcGill University · CAMéditerranée Infection Foundation · FRNational Institute for Communicable DiseasesOslo University Hospital · NOSheba Medical Center · ILThe Royal Melbourne Hospital · AUUniversité de Montréal · CAUniversity of Toronto · CAUniversity of Utah · USUniversity of Zurich · CHWorldwise Travellers Health & Vaccination Centres · NZ

Funding

NCEZID CDC HHS U50 CK000189
6 · The paper itself

Abstract

backgroundRecent studies demonstrate that rabies post-exposure prophylaxis (RPEP) in international travelers is suboptimal, with only 5-20% of travelers receiving rabies immune globulin (RIG) in the country of exposure when indicated. We hypothesized that travelers may not be receiving RIG appropriately, and practices may vary between countries. We aim to describe the characteristics of travelers who received RIG and/or RPEP during travel. METHODOLOGY/PRINCIPAL

findingsWe conducted a multi-center review of international travelers exposed to potentially rabid animals, collecting information on RPEP administration. Travelers who started RPEP before (Group A) and at (Group B) presentation to a GeoSentinel clinic during September 2014-July 2017 were included. We included 920 travelers who started RPEP. About two-thirds of Group A travelers with an indication for rabies immunoglobulin (RIG) did not receive it. Travelers exposed in Indonesia were less likely to receive RIG in the country of exposure (relative risk: 0.30; 95% confidence interval: 0.12-0.73; P = 0.01). Travelers exposed in Thailand [Relative risk (RR) 1.38, 95% Confidence Interval (95% CI): 1.0-1.8; P = 0.02], Sri Lanka (RR 3.99, 95% CI: 3.99-11.9; P = 0.013), and the Philippines (RR 19.95, 95% CI: 2.5-157.2; P = 0.01), were more likely to receive RIG in the country of exposure. CONCLUSIONS/SIGNIFICANCE: This analysis highlights gaps in early delivery of RIG to travelers and identifies specific countries where travelers may be more or less likely to receive RIG. More detailed country-level information helps inform risk education of international travelers regarding appropriate rabies prevention.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, ViralChildChild, PreschoolFemaleHumansIndonesiaMaleMiddle AgedPost-Exposure ProphylaxisRabiesRabies virusRisk AssessmentAntibodies, Viral

Identifiers

PMID30422981
PMCPMC6258561
OpenAlexW2900668819

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.