ReviewCurrent opinion in rheumatology2019
New insights into IgG4-related disease: emerging new CD4+ T-cell subsets.
Review in Current opinion in rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Inflammaging reshapes the immune ecosystem in IgG4-related dacryoadenitis and sialadenitis.Rheumatology (Oxford, England) · 2026Article
- Association of Th2-like inflammation with Tfh/Tph-germinal center immune programmes in submandibular gland lesions of IgG4-related disease.Rheumatology (Oxford, England) · 2026Article
- [Rational diagnostics and differential diagnosis in IgG4-related disease].Zeitschrift fur Rheumatologie · 2026Review
- Expansion of peripheral helper T cells in the peripheral blood of patients with chronic graft-versus-host disease.Annals of hematology · 2025Article
- Occurrence and role of Tph cells in various renal diseases.Molecular medicine (Cambridge, Mass.) · 2024Review
- Single-Cell RNA-Sequencing Reveals Peripheral T Helper Cells Promoting the Development of IgG4-Related Disease by Enhancing B Cell Activation and Differentiation.International journal of molecular sciences · 2023Article
- Immunoglobulin G4-related Disease with Marked Eosinophilia: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- IgG4-related disease with kidney and lymph nodes involvement: a case-based review.Rheumatology international · 2023Review
- Immune phenotype changes in IgG4-related disease: CD161 + Treg and Foxp3 + Treg.Clinical rheumatology · 2023Article
- [Immunoglobulin G (IgG) 4-related diseases].Zeitschrift fur Rheumatologie · 2022Article
- IL-7 Promotes the Expansion of Circulating CD28- Cytotoxic T Lymphocytes in Patients With IgG4-Related DiseaseFrontiers in immunology · 2022Article
- T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis.Autoimmune diseases · 2022Review
- Single-Cell Sequencing of Immune Cell Heterogeneity in IgG4-Related Disease.Frontiers in immunology · 2022Article
- Significance of high serum IgG4 in complete or non-full-fledged IgG4-related disease-a retrospective investigation of 845 patients and its clinical relevance.Clinical rheumatology · 2022Article
- Differential IgG4-Producing Plasma Cell Infiltration in Non- and Post-Transplant Plasma Cell Hepatitis.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- Patterns of T-Cell Phenotypes in Rheumatic Diseases From Single-Cell Studies of Tissue.ACR open rheumatology · 2021Review
- IgG4-related gastric disease with plasma cell-rich obliterative arteritis accompanied by early-stage gastric cancer: a case report.Surgical case reports · 2021Article
- Association of circulating SLAMF7BMC immunology · 2020Article
- Multi-marker algorithms based on CXCL13, IL-10, sIL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose CNS lymphoma.Cancer medicine · 2020Article
- Expansion of a Novel Subset of PD1+CXCR5-CD4+ T Peripheral Helper Cells in IgG4-Related Disease.Clinical and translational gastroenterology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewNew insights into IgG4-related disease (IgG4-RD) have recently been obtained. A better understanding of the mechanisms underlying this disease is important for identification of therapeutic targets, which will lead to the development of specific strategies for treatment. RECENT
findingsInfiltration of activated T follicular helper (Tfh) cells is observed in affected tissues of IgG4-RD. Such Tfh cells have a greater capacity than tonsillar Tfh cells to help B cells produce IgG4. Circulating PD-1CXCR5 peripheral T helper (Tph)-like cells are also increased in patients with IgG4-RD. Because Tph-like cells express high levels of chemokine receptors and granzyme A, they have the capacity to infiltrate affected tissues and exert a cytotoxic function. Tph-like cells can also produce CXCL13, and CXCR5 Tfh cells and B cells are therefore preferentially recruited to form ectopic lymphoid structures in the sites. Tph cells may have a role to ignite inflammation and maintain persistent fibroinflammation in collaboration with Tfh cells in lesions of IgG4-RD. SUMMARY: Recent advances in understanding the pathogenesis of IgG4-RD are remarkable. In this review, we summarize and discuss the possible pathologic role of CD4 T-cell subsets in IgG4-RD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.