Evidence map›Paper›PMID 30422673›Full record

ReviewCanadian journal of physiology and pharmacology2019

Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition

Avisek Majumder, Mahavir Singh, Akash K George, Suresh C Tyagi

Open access · greenAbstract readReview
In one paragraph

Review in Canadian journal of physiology and pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. HHandbook of experimental pharmacology · 2026
    Review
  2. Article
  3. CSE/HInternational journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. The preventive effect ofToxicological research · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Development of AD-Like Pathology in Skeletal Muscle.Journal of Parkinson's disease and Alzheimer's disease · 2019
    Article
  18. Imbalance of Homocysteine and HOxidative medicine and cellular longevity · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Avisek Majumdera Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Mahavir Singha Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Akash K Georgea Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
Suresh C Tyagia Department of Physiology, University of Louisville School of Medicine, Louisville, KY 40202, USA.
University of Louisville · US

Funding

FOCUS Data Coordinating CenterU01HL074815 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI TERRIN, MICHAEL L · 2003 to 2010
$2.9M
Mechanisms of Homocysteine-Induced Fibrinogen-Amyloid Plaque FormationR01NS084823 · NINDS · UNIVERSITY OF LOUISVILLE · PI LOMINADZE, DAVID, TYAGI, SURESH C. · 2013 to 2017
$2.7M
Mechanisms of Mitochondrial Dysfunction in Brain VasculatureR01HL107640 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU · 2012 to 2016
$1.8M
Reversing Skeletal Muscle Myopathy by Hydrogen SulfideR01AR071789 · NIAMS · UNIVERSITY OF LOUISVILLE · PI TYAGI, SURESH C. · 2018 to 2023
$1.7M
NHLBI NIH HHS R01 HL107640NHLBI NIH HHS U01 HL074815NIAMS NIH HHS R01 AR071789NINDS NIH HHS R01 NS084823
6 · The paper itself

Abstract

Elevated homocysteine (Hcy), i.e., hyperhomocysteinemia (HHcy), causes skeletal muscle myopathy. Among many cellular and metabolic alterations caused by HHcy, oxidative and endoplasmic reticulum (ER) stress are considered the major ones; however, the precise molecular mechanism(s) in this process is unclear. Nevertheless, there is no treatment option available to treat HHcy-mediated muscle injury. Hydrogen sulfide (H

Indexed as

Endoplasmic Reticulum StressHomeostasisOxidative StressAnimalsHumansHydrogen SulfideHyperhomocysteinemiaMuscle, SkeletalHydrogen Sulfideangiogenèseangiogenesisapoptoseapoptosisatrophieatrophycystathionine-β synthasedéséquilibre redox (dérivés réactifs de l’oxygène)endoplasmic reticulum stressinflammationischemiaischémieJNKmyopathiemyopathyredox imbalance (ROS)stress du réticulum endoplasmique

Identifiers

PMID30422673
PMCPMC6719301
OpenAlexW2901074147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.